Title |
Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night
|
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Published in |
eLife, November 2016
|
DOI | 10.7554/elife.17267 |
Pubmed ID | |
Authors |
Lyle Muller, Giovanni Piantoni, Dominik Koller, Sydney S Cash, Eric Halgren, Terrence J Sejnowski |
Abstract |
During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity. These circular patterns repeat over hours of sleep with millisecond temporal precision, allowing reinforcement of the activity patterns through hundreds of reverberations. These results provide a novel mechanistic account for how global sleep oscillations and synaptic plasticity could strengthen networks distributed across the cortex to store coherent and integrated memories. |
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Geographical breakdown
Country | Count | As % |
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United States | 17 | 30% |
Switzerland | 4 | 7% |
United Kingdom | 3 | 5% |
Netherlands | 3 | 5% |
Japan | 2 | 4% |
China | 1 | 2% |
Mexico | 1 | 2% |
Brazil | 1 | 2% |
Austria | 1 | 2% |
Other | 4 | 7% |
Unknown | 19 | 34% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 34 | 61% |
Scientists | 15 | 27% |
Practitioners (doctors, other healthcare professionals) | 4 | 7% |
Science communicators (journalists, bloggers, editors) | 3 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Colombia | 1 | <1% |
Netherlands | 1 | <1% |
United Kingdom | 1 | <1% |
France | 1 | <1% |
Greece | 1 | <1% |
China | 1 | <1% |
Unknown | 198 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 29% |
Researcher | 42 | 20% |
Student > Bachelor | 19 | 9% |
Student > Master | 17 | 8% |
Professor | 13 | 6% |
Other | 27 | 13% |
Unknown | 30 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 71 | 34% |
Agricultural and Biological Sciences | 23 | 11% |
Psychology | 23 | 11% |
Engineering | 14 | 7% |
Medicine and Dentistry | 12 | 6% |
Other | 22 | 11% |
Unknown | 42 | 20% |