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Mendeley readers
Attention Score in Context
| Title |
From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health
|
|---|---|
| Published in |
Antioxidants & Redox Signaling, July 2007
|
| DOI | 10.1089/ars.2007.1528 |
| Pubmed ID | |
| Authors |
Laura Vanda Papp, Jun Lu, Arne Holmgren, Kum Kum Khanna |
| Abstract |
The requirement of the trace element selenium for life and its beneficial role in human health has been known for several decades. This is attributed to low molecular weight selenium compounds, as well as to its presence within at least 25 proteins, named selenoproteins, in the form of the amino acid selenocysteine (Sec). Incorporation of Sec into selenoproteins employs a unique mechanism that involves decoding of the UGA codon. This process requires multiple features such as the selenocysteine insertion sequence (SECIS) element and several protein factors including a specific elongation factor EFSec and the SECIS binding protein 2, SBP2. The function of most selenoproteins is currently unknown; however, thioredoxin reductases (TrxR), glutathione peroxidases (GPx) and thyroid hormone deiodinases (DIO) are well characterised selenoproteins involved in redox regulation of intracellular signalling, redox homeostasis and thyroid hormone metabolism. Recent evidence points to a role for selenium compounds as well as selenoproteins in the prevention of some forms of cancer. A number of clinical trials are either underway or being planned to examine the effects of selenium on cancer incidence. In this review we describe some of the recent progress in our understanding of the mechanism of selenoprotein synthesis, the role of selenoproteins in human health and disease and the therapeutic potential of some of these proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 580 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 3 | <1% |
| Spain | 2 | <1% |
| Brazil | 2 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Chile | 1 | <1% |
| Qatar | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 564 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 108 | 19% |
| Student > Master | 86 | 15% |
| Student > Bachelor | 67 | 12% |
| Researcher | 63 | 11% |
| Student > Doctoral Student | 46 | 8% |
| Other | 98 | 17% |
| Unknown | 112 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 150 | 26% |
| Biochemistry, Genetics and Molecular Biology | 74 | 13% |
| Medicine and Dentistry | 66 | 11% |
| Chemistry | 46 | 8% |
| Environmental Science | 15 | 3% |
| Other | 80 | 14% |
| Unknown | 149 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2023.
All research outputs
#1,661,016
of 23,437,201 outputs
Outputs from Antioxidants & Redox Signaling
#73
of 1,923 outputs
Outputs of similar age
#3,118
of 69,318 outputs
Outputs of similar age from Antioxidants & Redox Signaling
#1
of 14 outputs
Altmetric has tracked 23,437,201 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,923 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.