↓ Skip to main content

Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo

Overview of attention for article published in Diabetes, December 2005
Altmetric Badge

About this Attention Score

  • High Attention Score compared to outputs of the same age (80th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
116 Dimensions

Readers on

mendeley
102 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo
Published in
Diabetes, December 2005
DOI 10.2337/diabetes.54.12.3343
Pubmed ID
Authors

Susanna Freude, Leona Plum, Jessika Schnitker, Uschi Leeser, Michael Udelhoven, Wilhelm Krone, Jens C. Bruning, Markus Schubert

Abstract

Cerebral insulin receptors play an important role in regulation of energy homeostasis and development of neurodegeneration. Accordingly, type 2 diabetes characterized by insulin resistance is associated with an increased risk of developing Alzheimer's disease. Formation of neurofibrillary tangles, which contain hyperphosphorylated tau, represents a key step in the pathogenesis of neurodegenerative diseases. Here, we directly addressed whether peripheral hyperinsulinemia as one feature of type 2 diabetes can alter in vivo cerebral insulin signaling and tau phosphorylation. Peripheral insulin stimulation rapidly increased insulin receptor tyrosine phosphorylation, mitogen-activated protein kinase and phosphatidylinositol (PI) 3-kinase pathway activation, and dose-dependent tau phosphorylation at Ser202 in the central nervous system. Phospho-FoxO1 and PI-3,4,5-phosphate immunostainings of brains from insulin-stimulated mice showed neuronal staining throughout the brain, not restricted to brain areas without functional blood-brain barrier. Importantly, in insulin-stimulated neuronal/brain-specific insulin receptor knockout mice, cerebral insulin receptor signaling and tau phosphorylation were completely abolished. Thus, peripherally injected insulin directly targets the brain and causes rapid cerebral insulin receptor signal transduction and site-specific tau phosphorylation in vivo, revealing new insights into the linkage of type 2 diabetes and neurodegeneration.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
United States 2 2%
Unknown 98 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 22%
Student > Ph. D. Student 18 18%
Student > Master 9 9%
Professor 8 8%
Student > Bachelor 8 8%
Other 22 22%
Unknown 15 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 19%
Medicine and Dentistry 15 15%
Biochemistry, Genetics and Molecular Biology 13 13%
Neuroscience 12 12%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Other 15 15%
Unknown 22 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2010.
All research outputs
#5,682,240
of 22,705,019 outputs
Outputs from Diabetes
#3,137
of 9,196 outputs
Outputs of similar age
#28,092
of 146,265 outputs
Outputs of similar age from Diabetes
#32
of 66 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 9,196 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.