| Title |
What’s Behind the Decline? The Role of White Matter in Brain Aging
|
|---|---|
| Published in |
Neurochemical Research, April 2007
|
| DOI | 10.1007/s11064-007-9341-x |
| Pubmed ID | |
| Authors |
Jason D. Hinman, Carmela R. Abraham |
| Abstract |
The specific molecular events that underlie the age-related loss of cognitive function are poorly understood. Although not experimentally substantiated, age-dependent neuronal loss has long been considered central to age-related cognitive decline. More recently, age-related changes in brain white matter have taken precedence in explaining the steady decline in cognitive domains seen in non-diseased elderly. Characteristic alterations in the ultrastructure of myelin coupled with evidence of inflammatory processes present in the white matter of several different species suggest that specific molecular events within brain white matter may better explain observed pathological changes and cognitive deficits. This review focuses on recent evidence highlighting the importance of white matter in deciphering the course of "normal" brain aging. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| United Kingdom | 2 | 2% |
| Portugal | 1 | 1% |
| Unknown | 79 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 24% |
| Researcher | 13 | 15% |
| Professor | 10 | 12% |
| Professor > Associate Professor | 7 | 8% |
| Other | 5 | 6% |
| Other | 18 | 21% |
| Unknown | 12 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 26% |
| Medicine and Dentistry | 12 | 14% |
| Psychology | 11 | 13% |
| Neuroscience | 10 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 8 | 9% |
| Unknown | 18 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2021.
All research outputs
#3,509,790
of 22,705,019 outputs
Outputs from Neurochemical Research
#244
of 2,088 outputs
Outputs of similar age
#10,775
of 73,968 outputs
Outputs of similar age from Neurochemical Research
#1
of 18 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,088 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 73,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.