Title |
Gene duplication and fragmentation in the zebra finch major histocompatibility complex
|
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Published in |
BMC Biology, April 2010
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DOI | 10.1186/1741-7007-8-29 |
Pubmed ID | |
Authors |
Christopher N Balakrishnan, Robert Ekblom, Martin Völker, Helena Westerdahl, Ricardo Godinez, Holly Kotkiewicz, David W Burt, Tina Graves, Darren K Griffin, Wesley C Warren, Scott V Edwards |
Abstract |
Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken Gallus gallus, the avian species with the best characterized MHC, possesses a highly streamlined minimal essential MHC, which is linked to resistance against specific pathogens. It remains unclear the extent to which this organization describes the situation in other birds and whether it represents a derived or ancestral condition. The sequencing of the zebra finch Taeniopygia guttata genome, in combination with targeted bacterial artificial chromosome (BAC) sequencing, has allowed us to characterize an MHC from a highly divergent and diverse avian lineage, the passerines. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 2% |
United States | 2 | 1% |
Portugal | 1 | <1% |
Czechia | 1 | <1% |
Germany | 1 | <1% |
Japan | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 129 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 25% |
Researcher | 30 | 22% |
Student > Master | 13 | 9% |
Professor | 12 | 9% |
Student > Doctoral Student | 10 | 7% |
Other | 21 | 15% |
Unknown | 18 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 94 | 68% |
Biochemistry, Genetics and Molecular Biology | 12 | 9% |
Medicine and Dentistry | 4 | 3% |
Immunology and Microbiology | 3 | 2% |
Business, Management and Accounting | 2 | 1% |
Other | 3 | 2% |
Unknown | 21 | 15% |