| Title |
Piperine in food: Interference in the pharmacokinetics of phenytoin
|
|---|---|
| Published in |
European Journal of Drug Metabolism and Pharmacokinetics, December 2001
|
| DOI | 10.1007/bf03226378 |
| Pubmed ID | |
| Authors |
T. Velpandian, R. Jasuja, R. K. Bhardwaj, J. Jaiswal, S. K. Gupta |
| Abstract |
This study was carried out to explore the effect of piperine-containing food in altering the pharmacokinetics of phenytoin, an anti-epileptic drug with a narrow therapeutic index. A preliminary pharmacokinetic study was carried out in mice by administering phenytoin (10 mg) orally, with or without piperine (0.6 mg). Subsequently, oral pharmacokinetics of phenytoin was carried out in six healthy volunteers in a crossover design. Phenytoin tablet (300 mg) was given 30 minutes after ingestion of a soup (melahu rasam) with or without black pepper. A further study of intavenous pharmacokinetics of phenytoin (1 mg) in rats with or without oral pretreatment with piperine (10 mg) was also conducted. The phenytoin concentration in the serum was analyzed by HPLC. The study showed a significant increase in the kinetic estimates of Ka, AUC(0-10) and AUC(0-infinity) in the piperine-fed mice. Similarly, in human volunteers piperine increased Ka, AUC(0-48), AUC(0-infinity), and delayed elimination of phenytoin. Intravenous phenytoin in the oral piperine-treated rat group showed a significant alteration in the elimination phase indicating its metabolic blockade. The significance of this finding in epileptic patients maintained on phenytoin therapy requires further investigation. This study may also have implications in the case of other drugs having a low therapeutic index. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Belgium | 1 | 2% |
| Unknown | 56 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 16% |
| Student > Master | 9 | 16% |
| Student > Bachelor | 9 | 16% |
| Researcher | 5 | 9% |
| Other | 3 | 5% |
| Other | 11 | 19% |
| Unknown | 12 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 24% |
| Medicine and Dentistry | 8 | 14% |
| Agricultural and Biological Sciences | 8 | 14% |
| Chemistry | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 17 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2020.
All research outputs
#2,715,924
of 22,901,818 outputs
Outputs from European Journal of Drug Metabolism and Pharmacokinetics
#16
of 423 outputs
Outputs of similar age
#6,105
of 124,551 outputs
Outputs of similar age from European Journal of Drug Metabolism and Pharmacokinetics
#1
of 1 outputs
Altmetric has tracked 22,901,818 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 423 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them