| Title |
Contrasting Patterns of Sequence Evolution at the Functionally Redundant bric à brac Paralogs in Drosophila melanogaster
|
|---|---|
| Published in |
Journal of Molecular Evolution, July 2009
|
| DOI | 10.1007/s00239-009-9265-y |
| Pubmed ID | |
| Authors |
Ryan D. Bickel, Wendy S. Schackwitz, Len A. Pennacchio, Sergey V. Nuzhdin, Artyom Kopp |
| Abstract |
Genes with overlapping expression and function may gradually diverge despite retaining some common functions. To test whether such genes show distinct patterns of molecular evolution within species, we examined sequence variation at the bric à brac (bab) locus of Drosophila melanogaster. This locus is composed of two anciently duplicated paralogs, bab1 and bab2, which are involved in patterning the adult abdomen, legs, and ovaries. We have sequenced the 148 kb genomic region spanning the bab1 and bab2 genes from 94 inbred lines of D. melanogaster sampled from a single location. Two non-coding regions, one in each paralog, appear to be under selection. The strongest evidence of directional selection is found in a region of bab2 that has no known functional role. The other region is located in the bab1 paralog and is known to contain a cis-regulatory element that controls sex-specific abdominal pigmentation. The coding region of bab1 appears to be under stronger functional constraint than the bab2 coding sequences. Thus, the two paralogs are evolving under different selective regimes in the same natural population, illuminating the different evolutionary trajectories of partially redundant duplicate genes. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 2 | 5% |
| France | 1 | 3% |
| United States | 1 | 3% |
| Unknown | 35 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 38% |
| Student > Ph. D. Student | 8 | 21% |
| Student > Master | 4 | 10% |
| Student > Doctoral Student | 3 | 8% |
| Professor | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 56% |
| Biochemistry, Genetics and Molecular Biology | 7 | 18% |
| Business, Management and Accounting | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Computer Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 5 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2011.
All research outputs
#4,676,928
of 22,705,019 outputs
Outputs from Journal of Molecular Evolution
#236
of 1,435 outputs
Outputs of similar age
#20,199
of 110,417 outputs
Outputs of similar age from Journal of Molecular Evolution
#1
of 5 outputs
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