| Title |
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
|
|---|---|
| Published in |
Acta Neuropathologica, July 2006
|
| DOI | 10.1007/s00401-006-0104-6 |
| Pubmed ID | |
| Authors |
Katrin Beyer |
| Abstract |
Alpha-synuclein aggregation is thought to be a key event in the pathogenesis of synucleinopathies. Although different alpha-synuclein alterations and modifications have been proposed to be responsible for early aggregation steps, the mechanisms underlying these events remain unclarified. Alpha-synuclein is a small protein localized to synaptic terminals and its intrinsic structure has been claimed to be an important factor for self-oligomerization and self-aggregation. Alpha-synuclein expression studies in cell cultures have demonstrated that posttranslational modifications, such as phosphorylation, oxidation, and sumoylation, are primarily involved in alpha-synuclein aggregation. Furthermore, in the last few years accumulating evidence has pointed to alternative splicing as a crucial mechanism in the development of neurodegenerative disorders. At least three different alpha-synuclein isoforms have been described as products of alternative splicing. Two of these isoforms (alpha-synuclein 112 and alpha-synuclein 126) are shorter proteins with probably altered functions and aggregation propensity. The present review attempts to summarize the data so far available on alpha-synuclein structure, posttranslational modifications, and alternative splicing as possible enhancers of aggregation. |
Mendeley readers
The data shown below were compiled from readership statistics for 271 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| United Kingdom | 3 | 1% |
| India | 2 | <1% |
| Netherlands | 1 | <1% |
| Chile | 1 | <1% |
| Argentina | 1 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 258 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 19% |
| Student > Master | 42 | 15% |
| Researcher | 39 | 14% |
| Student > Bachelor | 33 | 12% |
| Student > Doctoral Student | 10 | 4% |
| Other | 40 | 15% |
| Unknown | 55 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 25% |
| Biochemistry, Genetics and Molecular Biology | 44 | 16% |
| Medicine and Dentistry | 26 | 10% |
| Chemistry | 25 | 9% |
| Neuroscience | 22 | 8% |
| Other | 22 | 8% |
| Unknown | 63 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2022.
All research outputs
#2,167,702
of 23,221,875 outputs
Outputs from Acta Neuropathologica
#522
of 2,389 outputs
Outputs of similar age
#4,203
of 66,500 outputs
Outputs of similar age from Acta Neuropathologica
#3
of 11 outputs
Altmetric has tracked 23,221,875 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,500 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.