| Title |
The Pathophysiologic Basis of Secondary Narcolepsy and Hypersomnia
|
|---|---|
| Published in |
Current Neurology and Neuroscience Reports, February 2011
|
| DOI | 10.1007/s11910-011-0178-y |
| Pubmed ID | |
| Authors |
Takashi Kanbayashi, Yohei Sagawa, Fumi Takemura, Sachiko-Uemura Ito, Ko Tsutsui, Yasuo Hishikawa, Seiji Nishino |
| Abstract |
The symptoms of narcolepsy can occur during the course of other neurologic conditions (ie, symptomatic narcolepsy). Inherited disorders, tumors, and head trauma were the three most frequent causes for symptomatic narcolepsy. Other causes include multiple sclerosis (MS), vascular disorders, and encephalitis. Cerebrospinal fluid hypocretin-1 measures were carried out in some recent cases with symptomatic narcolepsy, and moderate decreases in hypocretin levels were seen in a large majority of these cases. Excessive daytime sleepiness (EDS) in these symptomatic cases was sometimes reversible with an improvement of the causative neurologic disorder and with an improvement of the hypocretin (orexin) status. Recently, we found that several symptomatic narcoleptic cases with MS show unique bilateral symmetric hypothalamic lesions associated with significant hypocretin ligand deficiency. In addition, these patients often share the clinical characteristics of neuromyelitis optica (NMO) and the detection of NMO-IgG (or anti-aquaporin-4 [AQP4] antibodies), suggesting a new clinical entity. Further studies of the involvement of the hypocretin system in symptomatic narcolepsy and EDS are helpful to understand the pathophysiologic mechanisms for occurrence of EDS and cataplexy. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 5% |
| Mexico | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 50 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 16% |
| Other | 8 | 15% |
| Researcher | 8 | 15% |
| Student > Ph. D. Student | 8 | 15% |
| Professor > Associate Professor | 4 | 7% |
| Other | 11 | 20% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 40% |
| Neuroscience | 5 | 9% |
| Agricultural and Biological Sciences | 3 | 5% |
| Psychology | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 9 | 16% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2013.
All research outputs
#4,569,519
of 22,705,019 outputs
Outputs from Current Neurology and Neuroscience Reports
#259
of 914 outputs
Outputs of similar age
#31,118
of 183,423 outputs
Outputs of similar age from Current Neurology and Neuroscience Reports
#2
of 7 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 914 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,423 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.