| Title |
Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study
|
|---|---|
| Published in |
Brain Imaging and Behavior, November 2007
|
| DOI | 10.1007/s11682-007-9012-1 |
| Pubmed ID | |
| Authors |
Shashwath A. Meda, Joel Gelernter, Jeffrey R. Gruen, Vince D. Calhoun, Haiying Meng, Natalie A. Cope, Godfrey D. Pearlson |
| Abstract |
OBJECTIVE: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. METHOD: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. RESULTS: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/para-hippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. CONCLUSIONS: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Netherlands | 2 | 3% |
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Spain | 1 | 1% |
| China | 1 | 1% |
| Unknown | 62 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 20% |
| Researcher | 10 | 14% |
| Professor | 9 | 13% |
| Student > Bachelor | 7 | 10% |
| Student > Master | 7 | 10% |
| Other | 16 | 23% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 25 | 35% |
| Agricultural and Biological Sciences | 13 | 18% |
| Neuroscience | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Engineering | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 12 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2009.
All research outputs
#6,660,136
of 26,017,215 outputs
Outputs from Brain Imaging and Behavior
#340
of 1,201 outputs
Outputs of similar age
#33,885
of 170,349 outputs
Outputs of similar age from Brain Imaging and Behavior
#1
of 3 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,201 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,349 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them