| Title |
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis
|
|---|---|
| Published in |
Immunologic Research, April 2013
|
| DOI | 10.1007/s12026-013-8413-z |
| Pubmed ID | |
| Authors |
Amy D. Proal, Paul J. Albert, Trevor G. Marshall, Greg P. Blaney, Inge A. Lindseth |
| Abstract |
Chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) has long been associated with the presence of infectious agents, but no single pathogen has been reliably identified in all patients with the disease. Recent studies using metagenomic techniques have demonstrated the presence of thousands of microbes in the human body that were previously undetected and unknown to science. More importantly, such species interact together by sharing genes and genetic function within communities. It follows that searching for a singular pathogen may greatly underestimate the microbial complexity potentially driving a complex disease like CFS/ME. Intracellular microbes alter the expression of human genes in order to facilitate their survival. We have put forth a model describing how multiple species-bacterial, viral, and fungal-can cumulatively dysregulate expression by the VDR nuclear receptor in order to survive and thus drive a disease process. Based on this model, we have developed an immunostimulatory therapy that is showing promise inducing both subjective and objective improvement in patients suffering from CFS/ME. |
X Demographics
The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 13 | 19% |
| United States | 11 | 16% |
| Germany | 5 | 7% |
| Canada | 4 | 6% |
| Australia | 2 | 3% |
| Netherlands | 2 | 3% |
| France | 1 | 1% |
| Ireland | 1 | 1% |
| Comoros | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 28 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 58 | 84% |
| Scientists | 6 | 9% |
| Practitioners (doctors, other healthcare professionals) | 5 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| United States | 2 | 3% |
| United Kingdom | 1 | 1% |
| Unknown | 72 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 22% |
| Student > Master | 13 | 17% |
| Student > Bachelor | 9 | 12% |
| Student > Ph. D. Student | 7 | 9% |
| Student > Postgraduate | 7 | 9% |
| Other | 10 | 13% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 27% |
| Agricultural and Biological Sciences | 8 | 10% |
| Nursing and Health Professions | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Psychology | 5 | 6% |
| Other | 13 | 17% |
| Unknown | 16 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2023.
All research outputs
#933,959
of 25,708,267 outputs
Outputs from Immunologic Research
#33
of 950 outputs
Outputs of similar age
#6,654
of 213,264 outputs
Outputs of similar age from Immunologic Research
#5
of 21 outputs
Altmetric has tracked 25,708,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 950 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,264 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.