| Title |
Midlife managerial experience is linked to late life hippocampal morphology and function
|
|---|---|
| Published in |
Brain Imaging and Behavior, November 2016
|
| DOI | 10.1007/s11682-016-9649-8 |
| Pubmed ID | |
| Authors |
C. Suo, N. Gates, M. Fiatarone Singh, N. Saigal, G. C. Wilson, J. Meiklejohn, P. Sachdev, H. Brodaty, W. Wen, N. Singh, B. T. Baune, M. Baker, N. Foroughi, Y. Wang, Michael J. Valenzuela |
| Abstract |
An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life. Yet whether similar links exist in individuals with Mild Cognitive Impairment (MCI) is not known, nor whether these differences have any functional implications. 68 volunteers from the Sydney SMART Trial, diagnosed with non-amnestic MCI, were divided into high and low managerial experience (HME/LME) during their working life. All participants underwent neuropsychological testing, structural and resting-state functional MRI. Group comparisons were performed on hippocampal volume, morphology, hippocampal seed-based functional connectivity, memory and executive function and self-ratings of memory proficiency. HME was linked to better memory function (p = 0.024), mediated by larger hippocampal volume (p = 0.025). More specifically, deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus (p < 0.05). Paradoxically, this group rated their memory proficiency worse (p = 0.004), a result correlated with diminished functional connectivity between the right hippocampus and right prefrontal cortex (p < 0.001). Finally, hierarchical regression modelling substantiated this double dissociation. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 25% |
| United Kingdom | 1 | 13% |
| Australia | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 50% |
| Members of the public | 4 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 14% |
| Student > Ph. D. Student | 13 | 13% |
| Student > Bachelor | 9 | 9% |
| Researcher | 9 | 9% |
| Student > Doctoral Student | 8 | 8% |
| Other | 16 | 16% |
| Unknown | 32 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 15 | 15% |
| Neuroscience | 14 | 14% |
| Psychology | 10 | 10% |
| Medicine and Dentistry | 7 | 7% |
| Unspecified | 5 | 5% |
| Other | 8 | 8% |
| Unknown | 42 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2016.
All research outputs
#2,301,944
of 23,577,761 outputs
Outputs from Brain Imaging and Behavior
#103
of 1,165 outputs
Outputs of similar age
#40,244
of 308,382 outputs
Outputs of similar age from Brain Imaging and Behavior
#7
of 62 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,165 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.