| Title |
Neuropsychological variability, symptoms, and brain imaging in chronic schizophrenia
|
|---|---|
| Published in |
Brain Imaging and Behavior, July 2012
|
| DOI | 10.1007/s11682-012-9193-0 |
| Pubmed ID | |
| Authors |
Paul G. Nestor, Marek Kubicki, Motoaki Nakamura, Margaret Niznikiewicz, James J. Levitt, Martha E. Shenton, Robert W. McCarley |
| Abstract |
We examined variability in performance on widely-used neuropsychological Wechsler tests of intelligence and memory in a large sample of persons with chronic schizophrenia, a subset of whom had also undergone prior studies of magnetic resonance imaging (MRI) of the orbital frontal cortex (OFC) gray matter and diffusion tensor imaging (DTI) of the cingulum bundle (CB) and the uncinate fasiculus (UF) white matter. In comparison to controls, persons with schizophrenia showed lower scores across neuropsychological tests, with most pronounced drops in processing speed and immediate memory, in relation to oral reading. For patients, greater declines in intelligence and memory each correlated with reduced CB white matter fractional anisotropy and reduced OFC gray matter, respectively. However, only memory decline correlated with severity of negative symptoms. Taken together, these data raise the intriguing question as to whether communication and motivational deficits expressed in negative symptoms may contribute to the relationship of auditory memory decline and OFC volume observed in this patient sample. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 19% |
| Researcher | 9 | 17% |
| Student > Master | 7 | 13% |
| Other | 4 | 7% |
| Student > Bachelor | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 17 | 31% |
| Medicine and Dentistry | 8 | 15% |
| Neuroscience | 7 | 13% |
| Agricultural and Biological Sciences | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 15 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2016.
All research outputs
#13,382,001
of 22,705,019 outputs
Outputs from Brain Imaging and Behavior
#503
of 1,151 outputs
Outputs of similar age
#90,698
of 164,643 outputs
Outputs of similar age from Brain Imaging and Behavior
#7
of 19 outputs
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