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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice
|
|---|---|
| Published in |
Scientific Reports, November 2016
|
| DOI | 10.1038/srep37171 |
| Pubmed ID | |
| Authors |
Kamila Jastrzębska, Magdalena Walczak, Przemysław Eligiusz Cieślak, Łukasz Szumiec, Mateusz Turbasa, David Engblom, Tomasz Błasiak, Jan Rodriguez Parkitna |
| Abstract |
The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA receptors on dopaminergic neurons in adult mice led to the development of affective disorder-like symptoms. The loss of NMDA receptors altered activity and caused complete NMDA-insensitivity in dopamine-like neurons. Mutant mice exhibited increased immobility in the forced swim test and a decrease in social interactions. Mutation also led to reduced saccharin intake, however the preference of sweet taste was not significantly decreased. Additionally, we found that while mutant mice were slower to learn instrumental tasks, they were able to reach the same performance levels, had normal sensitivity to feedback and showed similar motivation to exert effort as control animals. Taken together these results show that inducing the loss of NMDA receptor-dependent activity in dopamine neurons is associated with development of affective disorder-like symptoms. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 29% |
| Researcher | 10 | 20% |
| Student > Master | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Professor > Associate Professor | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 10 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 24% |
| Agricultural and Biological Sciences | 6 | 12% |
| Psychology | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Medicine and Dentistry | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 12 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2016.
All research outputs
#18,482,034
of 22,901,818 outputs
Outputs from Scientific Reports
#93,643
of 123,747 outputs
Outputs of similar age
#303,967
of 417,510 outputs
Outputs of similar age from Scientific Reports
#2,587
of 3,330 outputs
Altmetric has tracked 22,901,818 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 123,747 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 417,510 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,330 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.