| Chapter title |
Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
|
|---|---|
| Chapter number | 1 |
| Book title |
DNA Methyltransferases - Role and Function
|
| Published in |
Advances in experimental medicine and biology, November 2016
|
| DOI | 10.1007/978-3-319-43624-1_1 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-943622-7, 978-3-31-943624-1
|
| Authors |
Renata Z. Jurkowska, Albert Jeltsch |
| Editors |
Albert Jeltsch, Renata Z. Jurkowska |
| Abstract |
DNA methylation and DNA methyltransferases (MTases) - the enzymes that introduce the methylation mark into the DNA - have been studied for almost 70 years. In this chapter, we review key developments in the field that led to our current understanding of the structures and mechanisms of DNA MTases and the essential biological role of DNA methylation, including the discovery of DNA methylation and DNA MTases, the cloning and sequence analysis of bacterial and eukaryotic MTases, and the elucidation of their structure, mechanism, and regulation. We describe genetic studies that contributed greatly to the evolving views on the role of DNA methylation in human development and diseases, the invention of methods for the genome-wide analysis of DNA methylation, and the biochemical identification of DNA MTases and the family of TET enzymes, which are involved in DNA demethylation. We finish by highlighting critical questions for the next years of research in the field. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 27% |
| Student > Bachelor | 5 | 17% |
| Student > Doctoral Student | 3 | 10% |
| Professor | 2 | 7% |
| Student > Master | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 53% |
| Agricultural and Biological Sciences | 4 | 13% |
| Computer Science | 1 | 3% |
| Immunology and Microbiology | 1 | 3% |
| Unknown | 8 | 27% |