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DNA Methyltransferases - Role and Function

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Cover of 'DNA Methyltransferases - Role and Function'

Table of Contents

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    Book Overview
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    Chapter 1 Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
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    Chapter 2 DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
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    Chapter 3 Bacterial DNA Methylation and Methylomes.
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    Chapter 4 Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
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    Chapter 5 Enzymology of Mammalian DNA Methyltransferases.
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    Chapter 6 Genetic Studies on Mammalian DNA Methyltransferases.
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    Chapter 7 The Role of DNA Methylation in Cancer.
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    Chapter 8 DNA Methyltransferases - Role and Function
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    Chapter 9 DNA Methyltransferases - Role and Function
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    Chapter 10 N6-Methyladenine: A Conserved and Dynamic DNA Mark.
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    Chapter 11 Pathways of DNA Demethylation.
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    Chapter 12 Structure and Function of TET Enzymes.
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    Chapter 13 Proteins That Read DNA Methylation.
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    Chapter 14 DNA Methyltransferases - Role and Function
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    Chapter 15 DNA Methyltransferases - Role and Function
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    Chapter 16 DNA Methyltransferase Inhibitors: Development and Applications.
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    Chapter 17 DNA Methyltransferases - Role and Function
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    Chapter 18 Engineering and Directed Evolution of DNA Methyltransferases.
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    Chapter 19 DNA Labeling Using DNA Methyltransferases.
Attention for Chapter 12: Structure and Function of TET Enzymes.
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Chapter title
Structure and Function of TET Enzymes.
Chapter number 12
Book title
DNA Methyltransferases - Role and Function
Published in
Advances in experimental medicine and biology, November 2016
DOI 10.1007/978-3-319-43624-1_12
Pubmed ID
27826843
Book ISBNs
978-3-31-943622-7, 978-3-31-943624-1
Authors

Xiaotong Yin, Yanhui Xu

Editors

Albert Jeltsch, Renata Z. Jurkowska

Abstract

Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC). TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in various biological and pathological processes, including regulation of DNA demethylation, gene transcription, embryonic development, and oncogenesis. In this chapter, we will discuss the discovery of TET-mediated 5mC oxidation and the structure, function, and regulation of TET enzymes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 27%
Student > Bachelor 8 16%
Professor 3 6%
Student > Doctoral Student 2 4%
Researcher 2 4%
Other 3 6%
Unknown 18 37%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 33%
Chemistry 4 8%
Agricultural and Biological Sciences 4 8%
Immunology and Microbiology 2 4%
Environmental Science 1 2%
Other 2 4%
Unknown 20 41%

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