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Capturing Excited States in the Fast‐Intermediate Exchange Limit in Biological Systems Using 1H NMR Spectroscopy

Overview of attention for article published in Angewandte Chemie. International Edition, November 2016
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Title
Capturing Excited States in the Fast‐Intermediate Exchange Limit in Biological Systems Using 1H NMR Spectroscopy
Published in
Angewandte Chemie. International Edition, November 2016
DOI 10.1002/anie.201609102
Pubmed ID
Authors

Emilie Steiner, Judith Schlagnitweit, Patrik Lundström, Katja Petzold

Abstract

Changes in molecular structure are essential for the function of biomolecules. Characterization of these structural fluctuations can illuminate alternative states and help in correlating structure to function. NMR relaxation dispersion (RD) is currently the only method for detecting these alternative, high-energy states. In this study, we present a versatile (1) H R1ρ RD experiment that not only extends the exchange timescales at least three times beyond the rate limits of (13) C/(15) N R1ρ and ten times for CPMG experiments, but also makes use of easily accessible probes, thus allowing a general description of biologically important excited states. This technique can be used to extract chemical shifts for the structural characterization of excited states and to elucidate complex excited states.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Researcher 8 16%
Student > Doctoral Student 4 8%
Other 3 6%
Student > Postgraduate 3 6%
Other 10 20%
Unknown 12 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 35%
Chemistry 12 24%
Agricultural and Biological Sciences 3 6%
Physics and Astronomy 1 2%
Unspecified 1 2%
Other 2 4%
Unknown 14 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2017.
All research outputs
#16,061,963
of 25,394,764 outputs
Outputs from Angewandte Chemie. International Edition
#35,716
of 50,044 outputs
Outputs of similar age
#237,520
of 417,983 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#545
of 788 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 50,044 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 417,983 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 788 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.