| Title |
TNF-α in promotion and progression of cancer
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, September 2006
|
| DOI | 10.1007/s10555-006-9005-3 |
| Pubmed ID | |
| Authors |
Frances Balkwill |
| Abstract |
Tumour necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. In common with other family members, TNF-alpha is involved in maintenance and homeostasis of the immune system, inflammation and host defence. However, there is a 'dark side' to this powerful cytokine; it is now clear that, especially in middle and old age, TNF-alpha is involved in pathological processes such as chronic inflammation, autoimmunity and, in apparent contradiction to its name, malignant disease. This article will discuss the involvement of TNF-alpha in the inflammatory network that contributes to all stages of the malignant process, and consider the possibility that TNF-alpha may be a target for cancer therapy. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 545 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Argentina | 1 | <1% |
| France | 1 | <1% |
| Thailand | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 538 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 109 | 20% |
| Student > Master | 78 | 14% |
| Student > Bachelor | 77 | 14% |
| Researcher | 48 | 9% |
| Student > Doctoral Student | 31 | 6% |
| Other | 60 | 11% |
| Unknown | 142 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 103 | 19% |
| Biochemistry, Genetics and Molecular Biology | 95 | 17% |
| Medicine and Dentistry | 73 | 13% |
| Immunology and Microbiology | 35 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 3% |
| Other | 61 | 11% |
| Unknown | 163 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2024.
All research outputs
#1,747,383
of 25,998,826 outputs
Outputs from Cancer and Metastasis Reviews
#29
of 894 outputs
Outputs of similar age
#3,360
of 92,463 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#1
of 9 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 894 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,463 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them