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Associations between antipsychotics and risk of violent crimes and suicidal behaviour in personality disorder

Overview of attention for article published in BMJ Mental Health, October 2022
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

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1 blog
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39 X users

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3 Dimensions

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29 Mendeley
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Title
Associations between antipsychotics and risk of violent crimes and suicidal behaviour in personality disorder
Published in
BMJ Mental Health, October 2022
DOI 10.1136/ebmental-2022-300493
Pubmed ID
Authors

Kimmo Herttua, Mike Crawford, Tapio Paljarvi, Seena Fazel

Abstract

Despite uncertain benefits, people with personality disorder are commonly treated with antipsychotic medication. To investigate the association between antipsychotics and violent crimes and suicidal behaviour in individuals with personality disorder. We used nationwide Danish registries to identify all individuals with diagnosed personality disorder aged 18-64 years during 2007 to 2016. Antipsychotics were recorded in dispensed prescriptions, and individuals were followed up for police-recorded suspicions for violent crimes and healthcare presentations of suicidal behaviour. We applied a within-individual design where outcome rates for individuals with personality disorder during medicated periods were compared with rates during non-medicated periods. The cohort included 166 328 people with diagnosed personality disorder, of whom 79 253 were prescribed antipsychotics, presented at least one outcome and were thus included in the within-individual analyses. Compared with periods when individuals were not on antipsychotic medication, violent crime suspicions were 40% lower (incident rate ratio (IRR) 0.60, 95% CI 0.55 to 0.63) in men and 10% lower (IRR 0.90, 95% CI 0.79 to 1.01) in women, while rates of suicidal behaviour were 32% lower both in men (IRR 0.68, 95% CI 0.66 to 0.71) and in women (IRR 0.68, 95% CI 0.65 to 0.70). In subgroup analyses, the magnitude of the association varied across specific personality disorders for criminal outcomes but less for suicidal behaviour, with largest association in dissocial personality disorder for violent criminality (IRR 0.53, 95% CI 0.47 to 0.59). Treatment with antipsychotics was associated with reduced risks for violent crime suspicions and suicidal behaviour among individuals with personality disorder. Potential effects of antipsychotics on suicidal behaviour and violence should be taken into account when considering treatment options for people with personality disorders.

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X Demographics

The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 6 21%
Researcher 3 10%
Lecturer 2 7%
Student > Bachelor 2 7%
Professor > Associate Professor 2 7%
Other 4 14%
Unknown 10 34%
Readers by discipline Count As %
Unspecified 6 21%
Social Sciences 3 10%
Neuroscience 3 10%
Medicine and Dentistry 3 10%
Sports and Recreations 1 3%
Other 3 10%
Unknown 10 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2023.
All research outputs
#1,355,442
of 25,530,891 outputs
Outputs from BMJ Mental Health
#77
of 924 outputs
Outputs of similar age
#29,560
of 441,750 outputs
Outputs of similar age from BMJ Mental Health
#3
of 6 outputs
Altmetric has tracked 25,530,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 924 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.