| Title |
Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson’s Disease
|
|---|---|
| Published in |
Molecular Neurobiology, November 2016
|
| DOI | 10.1007/s12035-016-0258-8 |
| Pubmed ID | |
| Authors |
Ji-Yeun Park, Seung-Nam Kim, Junsang Yoo, Jaehwan Jang, Ahreum Lee, Ju-Young Oh, Hongwon Kim, Seung Tack Oh, Seong-Uk Park, Jongpil Kim, Hi-Joon Park, Songhee Jeon |
| Abstract |
Acupuncture has shown the therapeutic effect on various neurodegenerative disorders including Parkinson's disease (PD). While investigating the neuroprotective mechanism of acupuncture, we firstly found the novel function of melanin-concentrating hormone (MCH) as a potent neuroprotective candidate. Here, we explored whether hypothalamic MCH mediates the neuroprotective action of acupuncture. In addition, we aimed at evaluating the neuroprotective effects of MCH and elucidating underlying mechanism in vitro and in vivo PD models. First, we tested whether hypothalamic MCH mediates the neuroprotective effects of acupuncture by challenging MCH-R1 antagonist (i.p.) in mice PD model. We also investigated whether MCH has a beneficial role in dopaminergic neuronal protection in vitro primary midbrain and human neuronal cultures and in vivo MPTP-induced, Pitx3(-/-), and A53T mutant mice PD models. Transcriptomics followed by quantitative PCR and western blot analyses were performed to reveal the neuroprotective mechanism of MCH. We first found that hypothalamic MCH biosynthesis was directly activated by acupuncture treatment and that administration of an MCH-R1 antagonist reverses the neuroprotective effects of acupuncture. A novel finding is that MCH showed a beneficial role in dopaminergic neuron protection via downstream pathways related to neuronal survival. This is the first study to suggest the novel neuroprotective action of MCH as well as the involvement of hypothalamic MCH in the acupuncture effects in PD, which holds great promise for the application of MCH in the therapy of neurodegenerative diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Uruguay | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 40 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 31% |
| Student > Doctoral Student | 5 | 12% |
| Researcher | 5 | 12% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Master | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 29% |
| Medicine and Dentistry | 7 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Agricultural and Biological Sciences | 3 | 7% |
| Chemistry | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 8 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2021.
All research outputs
#2,293,828
of 22,901,818 outputs
Outputs from Molecular Neurobiology
#255
of 3,468 outputs
Outputs of similar age
#41,359
of 307,484 outputs
Outputs of similar age from Molecular Neurobiology
#12
of 107 outputs
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So far Altmetric has tracked 3,468 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.