Title |
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
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Published in |
Nature Genetics, August 2010
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DOI | 10.1038/ng.639 |
Pubmed ID | |
Authors |
Thorsten Thye, Fredrik O Vannberg, Sunny H Wong, Ellis Owusu-Dabo, Ivy Osei, John Gyapong, Giorgio Sirugo, Fatou Sisay-Joof, Anthony Enimil, Margaret A Chinbuah, Sian Floyd, David K Warndorff, Lifted Sichali, Simon Malema, Amelia C Crampin, Bagrey Ngwira, Yik Y Teo, Kerrin Small, Kirk Rockett, Dominic Kwiatkowski, Paul E Fine, Philip C Hill, Melanie Newport, Christian Lienhardt, Richard A Adegbola, Tumani Corrah, Andreas Ziegler, Andrew P Morris, Christian G Meyer, Rolf D Horstmann, Adrian V S Hill |
Abstract |
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. |
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Spain | 2 | <1% |
Thailand | 1 | <1% |
Switzerland | 1 | <1% |
Japan | 1 | <1% |
Finland | 1 | <1% |
Other | 0 | 0% |
Unknown | 269 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 21% |
Researcher | 57 | 20% |
Student > Master | 30 | 10% |
Student > Bachelor | 23 | 8% |
Professor | 22 | 8% |
Other | 60 | 21% |
Unknown | 35 | 12% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 57 | 20% |
Biochemistry, Genetics and Molecular Biology | 45 | 16% |
Immunology and Microbiology | 17 | 6% |
Social Sciences | 6 | 2% |
Other | 24 | 8% |
Unknown | 46 | 16% |