Title |
Using the blood concentration of 2,5-dimethylfuran as a marker for smoking
|
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Published in |
International Archives of Occupational and Environmental Health, March 1996
|
DOI | 10.1007/bf00381629 |
Pubmed ID | |
Authors |
D. L. Ashley, M. A. Bonin, B. Hamar, M. McGeehin |
Abstract |
Correct analysis of whole blood volatile organic compounds (VOCs) in evaluating possible exposure situations requires differentiation of smokers from nonsmokers. Whole blood concentrations of 2,5-dimethylfuran are determined using an internal standard method, and the concentrations of this compound are evaluated as a marker for smoking in exposure-study subjects. Results indicate that the concentration of 2,5-dimethylfuran can be adequately determined in whole blood by a method already in use for determining VOCs in blood. The whole blood concentration of 2,5-dimethylfuran was an excellent predictor of smoking when compared with positive responses about smoking on questionnaires. Using a detection limit of 0.024 ppb, 2,5-dimethylfuran concentrations in blood correctly identified the smoking status of 96.4% of the subjects in this study. The blood 2,5-dimethylfuran concentration was linearly related to the number of cigarettes smoked per day. This method is advantageous since blood 2,5-dimethylfuran concentrations can be determined using the same method used to determine concentrations of other VOCs, thus obviating the need for additional analytical procedures. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 21% |
Other | 3 | 16% |
Student > Bachelor | 2 | 11% |
Student > Master | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Other | 3 | 16% |
Unknown | 3 | 16% |
Readers by discipline | Count | As % |
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Environmental Science | 3 | 16% |
Psychology | 3 | 16% |
Chemistry | 3 | 16% |
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Other | 4 | 21% |