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Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Overview of attention for article published in Trends in Cancer, November 2016
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Title
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Published in
Trends in Cancer, November 2016
DOI 10.1016/j.trecan.2016.10.009
Pubmed ID
Authors

Xiaonan Zhang, Angelo De Milito, Asuman Demiroglu-Zergeroglu, Joachim Gullbo, Padraig D’Arcy, Stig Linder

Abstract

The presence of quiescent cell populations in solid tumors represents a major challenge for disease eradication. Such cells are generally present in poorly vascularized tumor areas, show limited sensitivity to traditional chemotherapeutical drugs, and tend to resume proliferation, resulting in tumor reseeding and growth. There is growing recognition of the importance of developing therapies that target these quiescent cell populations to achieve long-lasting remission. Recent studies have shown that the combination of hypoxia and reduced nutrient availability in poorly vascularized areas results in limited tumor metabolic plasticity coupled with an increased sensitivity to perturbations in mitochondrial flux. Targeting of mitochondrial bioenergetics in these quiescent cell tumor populations may enable tumor eradication and improve the prognosis of patients with cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 20%
Researcher 5 13%
Student > Ph. D. Student 5 13%
Student > Doctoral Student 4 10%
Professor > Associate Professor 3 8%
Other 5 13%
Unknown 10 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 23%
Agricultural and Biological Sciences 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Medicine and Dentistry 2 5%
Engineering 2 5%
Other 4 10%
Unknown 14 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2018.
All research outputs
#15,740,207
of 25,374,647 outputs
Outputs from Trends in Cancer
#720
of 840 outputs
Outputs of similar age
#182,008
of 316,741 outputs
Outputs of similar age from Trends in Cancer
#26
of 29 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 840 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,741 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.