| Title |
Genomic and genealogical investigation of the French Canadian founder population structure
|
|---|---|
| Published in |
Human Genetics, January 2011
|
| DOI | 10.1007/s00439-010-0945-x |
| Pubmed ID | |
| Authors |
Marie-Hélène Roy-Gagnon, Claudia Moreau, Claude Bherer, Pascal St-Onge, Daniel Sinnett, Catherine Laprise, Hélène Vézina, Damian Labuda |
| Abstract |
Characterizing the genetic structure of worldwide populations is important for understanding human history and is essential to the design and analysis of genetic epidemiological studies. In this study, we examined genetic structure and distant relatedness and their effect on the extent of linkage disequilibrium (LD) and homozygosity in the founder population of Quebec (Canada). In the French Canadian founder population, such analysis can be performed using both genomic and genealogical data. We investigated genetic differences, extent of LD, and homozygosity in 140 individuals from seven sub-populations of Quebec characterized by different demographic histories reflecting complex founder events. Genetic findings from genome-wide single nucleotide polymorphism data were correlated with genealogical information on each of these sub-populations. Our genomic data showed significant population structure and relatedness present in the contemporary Quebec population, also reflected in LD and homozygosity levels. Our extended genealogical data corroborated these findings and indicated that this structure is consistent with the settlement patterns involving several founder events. This provides an independent and complementary validation of genomic-based studies of population structure. Combined genomic and genealogical data in the Quebec founder population provide insights into the effects of the interplay of two important sources of bias in genetic epidemiological studies, unrecognized genetic structure and cryptic relatedness. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Lebanon | 1 | 2% |
| United States | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 51 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Researcher | 10 | 18% |
| Student > Master | 8 | 15% |
| Student > Bachelor | 7 | 13% |
| Other | 6 | 11% |
| Other | 11 | 20% |
| Unknown | 2 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 40% |
| Biochemistry, Genetics and Molecular Biology | 11 | 20% |
| Social Sciences | 6 | 11% |
| Medicine and Dentistry | 6 | 11% |
| Neuroscience | 3 | 5% |
| Other | 5 | 9% |
| Unknown | 2 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2022.
All research outputs
#761,754
of 22,707,247 outputs
Outputs from Human Genetics
#55
of 2,950 outputs
Outputs of similar age
#4,002
of 194,885 outputs
Outputs of similar age from Human Genetics
#2
of 13 outputs
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