| Title |
Structure of centromere chromatin: from nucleosome to chromosomal architecture
|
|---|---|
| Published in |
Chromosoma, November 2016
|
| DOI | 10.1007/s00412-016-0620-7 |
| Pubmed ID | |
| Authors |
Thomas Schalch, Florian A. Steiner |
| Abstract |
The centromere is essential for the segregation of chromosomes, as it serves as attachment site for microtubules to mediate chromosome segregation during mitosis and meiosis. In most organisms, the centromere is restricted to one chromosomal region that appears as primary constriction on the condensed chromosome and is partitioned into two chromatin domains: The centromere core is characterized by the centromere-specific histone H3 variant CENP-A (also called cenH3) and is required for specifying the centromere and for building the kinetochore complex during mitosis. This core region is generally flanked by pericentric heterochromatin, characterized by nucleosomes containing H3 methylated on lysine 9 (H3K9me) that are bound by heterochromatin proteins. During mitosis, these two domains together form a three-dimensional structure that exposes CENP-A-containing chromatin to the surface for interaction with the kinetochore and microtubules. At the same time, this structure supports the tension generated during the segregation of sister chromatids to opposite poles. In this review, we discuss recent insight into the characteristics of the centromere, from the specialized chromatin structures at the centromere core and the pericentromere to the three-dimensional organization of these regions that make up the functional centromere. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Czechia | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 159 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 24% |
| Student > Bachelor | 25 | 15% |
| Researcher | 21 | 13% |
| Student > Master | 17 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 19 | 12% |
| Unknown | 32 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 70 | 43% |
| Agricultural and Biological Sciences | 41 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Immunology and Microbiology | 2 | 1% |
| Medicine and Dentistry | 2 | 1% |
| Other | 9 | 6% |
| Unknown | 35 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2016.
All research outputs
#14,281,116
of 22,901,818 outputs
Outputs from Chromosoma
#552
of 759 outputs
Outputs of similar age
#224,858
of 417,510 outputs
Outputs of similar age from Chromosoma
#2
of 5 outputs
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