↓ Skip to main content

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

Overview of attention for article published in Nature Medicine, April 2013
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

blogs
1 blog
twitter
18 X users
patent
9 patents
f1000
1 research highlight platform

Citations

dimensions_citation
652 Dimensions

Readers on

mendeley
733 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
Published in
Nature Medicine, April 2013
DOI 10.1038/nm.3174
Pubmed ID
Authors

Felipe De Sousa E Melo, Xin Wang, Marnix Jansen, Evelyn Fessler, Anne Trinh, Laura P M H de Rooij, Joan H de Jong, Onno J de Boer, Ronald van Leersum, Maarten F Bijlsma, Hans Rodermond, Maartje van der Heijden, Carel J M van Noesel, Jurriaan B Tuynman, Evelien Dekker, Florian Markowetz, Jan Paul Medema, Louis Vermeulen

Abstract

Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine which patients will benefit most from adjuvant therapy and impedes the development of new targeted agents. More insight into the biological diversity of colon cancers, especially in relation to clinical features, is therefore needed. We demonstrate, using an unsupervised classification strategy involving over 1,100 individuals with colon cancer, that three main molecularly distinct subtypes can be recognized. Two subtypes have been previously identified and are well characterized (chromosomal-instable and microsatellite-instable cancers). The third subtype is largely microsatellite stable and contains relatively more CpG island methylator phenotype-positive carcinomas but cannot be identified on the basis of characteristic mutations. We provide evidence that this subtype relates to sessile-serrated adenomas, which show highly similar gene expression profiles, including upregulation of genes involved in matrix remodeling and epithelial-mesenchymal transition. The identification of this subtype is crucial, as it has a very unfavorable prognosis and, moreover, is refractory to epidermal growth factor receptor-targeted therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 733 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 11 2%
Germany 4 <1%
United Kingdom 3 <1%
France 2 <1%
Italy 2 <1%
Netherlands 2 <1%
Spain 2 <1%
Korea, Republic of 1 <1%
Switzerland 1 <1%
Other 7 <1%
Unknown 698 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 184 25%
Researcher 161 22%
Student > Master 77 11%
Student > Doctoral Student 40 5%
Student > Bachelor 40 5%
Other 108 15%
Unknown 123 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 195 27%
Medicine and Dentistry 190 26%
Biochemistry, Genetics and Molecular Biology 154 21%
Immunology and Microbiology 13 2%
Computer Science 11 2%
Other 35 5%
Unknown 135 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#1,304,113
of 25,403,829 outputs
Outputs from Nature Medicine
#2,876
of 9,328 outputs
Outputs of similar age
#9,971
of 210,261 outputs
Outputs of similar age from Nature Medicine
#31
of 120 outputs
Altmetric has tracked 25,403,829 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,328 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,261 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.