Title |
Warfarin: history, tautomerism and activity
|
---|---|
Published in |
Perspectives in Drug Discovery and Design, March 2010
|
DOI | 10.1007/s10822-010-9335-7 |
Pubmed ID | |
Authors |
William R. Porter |
Abstract |
The anticoagulant drug warfarin, normally administered as the racemate, can exist in solution in potentially as many as 40 topologically distinct tautomeric forms. Only 11 of these forms for each enantiomer can be distinguished by selected computational software commonly used to estimate octanol-water partition coefficients and/or ionization constants. The history of studies on warfarin tautomerism is reviewed, along with the implications of tautomerism to its biological properties (activity, protein binding and metabolism) and chemical properties (log P, log D, pK (a)). Experimental approaches to assessing warfarin tautomerism and computational results for different tautomeric forms are presented. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Bulgaria | 2 | 2% |
Netherlands | 1 | 1% |
Brazil | 1 | 1% |
United Kingdom | 1 | 1% |
Russia | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 80 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 15% |
Student > Bachelor | 13 | 15% |
Professor > Associate Professor | 8 | 9% |
Student > Master | 8 | 9% |
Student > Postgraduate | 7 | 8% |
Other | 16 | 18% |
Unknown | 23 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 19 | 22% |
Medicine and Dentistry | 9 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
Agricultural and Biological Sciences | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Other | 16 | 18% |
Unknown | 27 | 31% |