Title |
Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach
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Published in |
BMC Ecology and Evolution, February 2008
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DOI | 10.1186/1471-2148-8-67 |
Pubmed ID | |
Authors |
Kirsten A Bratke, Aoife McLysaght |
Abstract |
Poxviruses are important pathogens of humans, livestock and wild animals. These large dsDNA viruses have a set of core orthologs whose gene order is extremely well conserved throughout poxvirus genera. They also contain many genes with sequence and functional similarity to host genes which were probably acquired by horizontal gene transfer.Although phylogenetic trees can indicate the occurrence of horizontal gene transfer and even uncover multiple events, their use may be hampered by uncertainties in both the topology and the rooting of the tree. We propose to use synteny conservation around the horizontally transferred gene (HTgene) to distinguish between single and multiple events. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 3% |
United Kingdom | 2 | 3% |
Canada | 1 | 1% |
Mexico | 1 | 1% |
Korea, Republic of | 1 | 1% |
Spain | 1 | 1% |
Unknown | 63 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 24% |
Researcher | 15 | 21% |
Student > Bachelor | 6 | 8% |
Student > Master | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Other | 12 | 17% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 33 | 46% |
Biochemistry, Genetics and Molecular Biology | 11 | 15% |
Immunology and Microbiology | 4 | 6% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Social Sciences | 2 | 3% |
Other | 3 | 4% |
Unknown | 15 | 21% |