| Title |
The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties
|
|---|---|
| Published in |
Glycoconjugate Journal, January 2013
|
| DOI | 10.1007/s10719-012-9464-4 |
| Pubmed ID | |
| Authors |
Maria A. Souza, Fernanda C. Carvalho, Luciana P. Ruas, Rafael Ricci-Azevedo, Maria Cristina Roque-Barreira |
| Abstract |
Advances in the glycobiology and immunology fields have provided many insights into the role of carbohydrate-protein interactions in the immune system. We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response to certain pathological conditions, such as cancer and infections. The present review comprises four main themes: (1) an overview of plant lectins that exert immunomodulatory effects and the mechanisms accounting for these activities; (2) general characteristics of the immunomodulatory lectin ArtinM from the seeds of Artocarpus heterophyllus; (3) activation of innate immunity cells by ArtinM and consequent induction of Th1 immunity; (4) resistance conferred by ArtinM administration in infections with intracellular pathogens, such as Leishmania (Leishmania) major, Leishmania (Leishmania) amazonensis, and Paracoccidioides brasiliensis. We believe that this review will be a valuable resource for more studies in this relatively neglected area of research, which has the potential to reveal carbohydrate targets for novel prophylactic and therapeutic strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Czechia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 147 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 19% |
| Student > Ph. D. Student | 20 | 13% |
| Student > Master | 20 | 13% |
| Researcher | 17 | 11% |
| Professor | 8 | 5% |
| Other | 22 | 15% |
| Unknown | 35 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 21% |
| Biochemistry, Genetics and Molecular Biology | 30 | 20% |
| Immunology and Microbiology | 13 | 9% |
| Chemistry | 11 | 7% |
| Medicine and Dentistry | 8 | 5% |
| Other | 16 | 11% |
| Unknown | 40 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2017.
All research outputs
#16,722,190
of 25,374,917 outputs
Outputs from Glycoconjugate Journal
#686
of 929 outputs
Outputs of similar age
#188,633
of 290,318 outputs
Outputs of similar age from Glycoconjugate Journal
#1
of 5 outputs
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So far Altmetric has tracked 929 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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