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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human B‐cell memory is shaped by age‐ and tissue‐specific T‐independent and GC‐dependent events
|
|---|---|
| Published in |
European Journal of Immunology, December 2016
|
| DOI | 10.1002/eji.201646642 |
| Pubmed ID | |
| Authors |
Alaitz Aranburu, Eva Piano Mortari, Anwar Baban, Ezio Giorda, Simona Cascioli, Valentina Marcellini, Marco Scarsella, Sara Ceccarelli, Sandro Corbelli, Nicoletta Cantarutti, Rita De Vito, Alessandro Inserra, Luciana Nicolosi, Arnalda Lanfranchi, Fulvio Porta, Caterina Cancrini, Andrea Finocchi, Rita Carsetti |
| Abstract |
Switched and IgM memory B cells execute different and non-interchangeable functions. We studied memory B cells in children of different ages, in peripheral blood and spleen and compared them with those of children born asplenic or unable to build germinal centers. We show that, whereas switched memory B cells are mostly generated in the germinal centers at all ages, IgM memory B cells can be distinct in three types with different developmental history. Innate IgM memory B cells, the largest pool in infants, are generated in the spleen by a germinal center-independent mechanism. With age, if the spleen is present and germinal centers are functional, innate IgM memory B cells are remodelled and accumulate somaticmutations. The third type of IgM memory B cell a by-product ofthe germinal center reaction. Our data suggest that the B-cell memory developmental program is implemented during the first 5-6 years of life. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Malaysia | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 53 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 19% |
| Researcher | 9 | 17% |
| Student > Doctoral Student | 6 | 11% |
| Professor | 6 | 11% |
| Student > Master | 4 | 7% |
| Other | 8 | 15% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 16 | 30% |
| Medicine and Dentistry | 9 | 17% |
| Agricultural and Biological Sciences | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 14 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2021.
All research outputs
#913,566
of 24,508,104 outputs
Outputs from European Journal of Immunology
#37
of 6,808 outputs
Outputs of similar age
#19,381
of 430,286 outputs
Outputs of similar age from European Journal of Immunology
#2
of 37 outputs
Altmetric has tracked 24,508,104 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,808 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,286 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.