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Can maternal microchimeric cells influence the fetal response toward self antigens?

Overview of attention for article published in Chimerism, July 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

blogs
1 blog

Citations

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5 Dimensions

Readers on

mendeley
19 Mendeley
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Title
Can maternal microchimeric cells influence the fetal response toward self antigens?
Published in
Chimerism, July 2011
DOI 10.4161/chim.2.3.17589
Pubmed ID
Authors

Lucie Leveque, Kiarash Khosrotehrani

Abstract

The origins of autoimmunity are still elusive despite significant advances in immunology. There is cumulative evidence that, beyond simple genetics, the maternal environment plays a critical role in the development of common autoimmune disorders, such as multiple sclerosis or diabetes. In recent years, the trafficking of maternal cells to the offspring has been clearly demonstrated. This microchimerism represents the very first immunological event in fetal life. The number of persisting maternal cells has been associated with several autoimmune disorders such as systemic sclerosis, juvenile dermatomyositis and diabetes. The precise role of the maternal cells in these disorders remains unclear. Based on recent experimental work in an animal model of juvenile diabetes, we will discuss the possibility of maternal cells modifying the response of the developing fetal immunity towards self.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
United States 1 5%
Brazil 1 5%
Unknown 16 84%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 42%
Researcher 6 32%
Student > Master 3 16%
Student > Bachelor 2 11%
Student > Postgraduate 2 11%
Other 4 21%
Readers by discipline Count As %
Medicine and Dentistry 7 37%
Agricultural and Biological Sciences 5 26%
Immunology and Microbiology 5 26%
Neuroscience 2 11%
Computer Science 1 5%
Other 5 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2012.
All research outputs
#6,755,994
of 25,377,790 outputs
Outputs from Chimerism
#25
of 69 outputs
Outputs of similar age
#36,922
of 127,152 outputs
Outputs of similar age from Chimerism
#3
of 3 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 69 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,152 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.