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Altered Insular Function during Aberrant Salience Processing in Relation to the Severity of Psychotic Symptoms

Overview of attention for article published in Frontiers in Psychiatry, November 2016
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Title
Altered Insular Function during Aberrant Salience Processing in Relation to the Severity of Psychotic Symptoms
Published in
Frontiers in Psychiatry, November 2016
DOI 10.3389/fpsyt.2016.00189
Pubmed ID
Authors

Anna Walter, Claudia Suenderhauf, Renata Smieskova, Claudia Lenz, Fabienne Harrisberger, André Schmidt, Tobias Vogel, Undine E. Lang, Anita Riecher-Rössler, Anne Eckert, Stefan Borgwardt

Abstract

There is strong evidence for abnormal salience processing in patients with psychotic experiences. In particular, there are indications that the degree of aberrant salience processing increases with the severity of positive symptoms. The aim of the present study was to elucidate this relationship by means of brain imaging. Functional magnetic resonance imaging was acquired to assess hemodynamic responses during the Salience Attribution Test, a paradigm for reaction time that measures aberrant salience to irrelevant stimulus features. We included 42 patients who were diagnosed as having a psychotic disorder and divided them into two groups according to the severity of their positive symptoms. Whole brain analysis was performed using Statistical Parametric Mapping. We found no significant behavioral differences with respect to task performance. Patients with more positive symptoms showed increased hemodynamic responses in the left insula corresponding to aberrant salience than in patients with less positive symptoms. In addition, left insula activation correlated negatively with cumulative antipsychotic medication. Aberrant salience processing in the insula may be increased in psychosis, depending on the severity of positive symptoms. This study indicates that clinically similar psychosis manifestations share the same functional characteristics. In addition, our results suggest that antipsychotic medication can modulate insular function.

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Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Student > Ph. D. Student 7 14%
Student > Master 3 6%
Student > Bachelor 3 6%
Student > Doctoral Student 2 4%
Other 8 16%
Unknown 17 34%
Readers by discipline Count As %
Medicine and Dentistry 10 20%
Psychology 9 18%
Neuroscience 8 16%
Agricultural and Biological Sciences 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 1 2%
Unknown 20 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2016.
All research outputs
#18,483,671
of 22,903,988 outputs
Outputs from Frontiers in Psychiatry
#6,898
of 10,058 outputs
Outputs of similar age
#303,066
of 415,120 outputs
Outputs of similar age from Frontiers in Psychiatry
#34
of 41 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,058 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.