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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic Architecture of Carotid Artery Intima-Media Thickness in Mexican Americans
|
|---|---|
| Published in |
Circulation: Genomic and Precision Medicine, March 2013
|
| DOI | 10.1161/circgenetics.113.000079 |
| Pubmed ID | |
| Authors |
Phillip E. Melton, Melanie A. Carless, Joanne E. Curran, Thomas D. Dyer, Harald H.H. Göring, Jack W. Kent, Eugene Drigalenko, Matthew P. Johnson, Jean W. MacCluer, Eric K. Moses, Anthony G. Comuzzie, Michael C. Mahaney, Daniel H. O’Leary, John Blangero, Laura Almasy |
| Abstract |
BACKGROUND- Intima-media thickness (IMT) of the common and internal carotid arteries is an established surrogate for atherosclerosis and predicts risk of stroke and myocardial infarction. Often IMT is measured as the average of these 2 arteries; yet, they are believed to result from separate biological mechanisms. The aim of this study was to conduct a family-based genome-wide association study (GWAS) for IMT to identify polymorphisms influencing IMT and to determine if distinct carotid artery segments are influenced by different genetic components. METHODS AND RESULTS- IMT for the common and internal carotid arteries was determined through B-mode ultrasound in 772 Mexican Americans from the San Antonio Family Heart Study. A GWAS using 931219 single-nucleotide polymorphisms was undertaken with 6 internal and common carotid artery IMT phenotypes using an additive measured genotype model. The most robust association detected was for 2 single-nucleotide polymorphisms (rs16983261, rs6113474; P=1.60e(-7)) in complete linkage disequilibrium on chromosome 20p11 for the internal carotid artery near wall, next to the gene PAX1. We also replicated previously reported GWAS regions on chromosomes 19q13 and 7q22. We found no overlapping associations between internal and common carotid artery phenotypes at P<5.0e(-6). The genetic correlation between the 2 carotid IMT arterial segments was 0.51. CONCLUSIONS- This study represents the first large-scale GWAS of carotid IMT in a non-European population and identified several novel loci. We do not detect any shared GWAS signals between common and internal carotid arterial segments, but the moderate genetic correlation implies both common and unique genetic components. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 4% |
| United States | 1 | 4% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 25% |
| Professor | 5 | 18% |
| Researcher | 5 | 18% |
| Student > Master | 4 | 14% |
| Student > Postgraduate | 2 | 7% |
| Other | 5 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 29% |
| Medicine and Dentistry | 8 | 29% |
| Agricultural and Biological Sciences | 8 | 29% |
| Nursing and Health Professions | 2 | 7% |
| Immunology and Microbiology | 1 | 4% |
| Other | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2013.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Circulation: Genomic and Precision Medicine
#908
of 1,062 outputs
Outputs of similar age
#160,973
of 208,880 outputs
Outputs of similar age from Circulation: Genomic and Precision Medicine
#9
of 13 outputs
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So far Altmetric has tracked 1,062 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.9. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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