Title |
Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals
|
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Published in |
Gastroenterology, April 2013
|
DOI | 10.1053/j.gastro.2013.04.010 |
Pubmed ID | |
Authors |
Elisa Fabbrini, Marina Cella, Steve A. Mccartney, Anja Fuchs, Nada A. Abumrad, Terri A. Pietka, Zhouji Chen, Brian N. Finck, Dong Ho Han, Faidon Magkos, Caterina Conte, David Bradley, Gemma Fraterrigo, J. Christopher Eagon, Bruce W. Patterson, Marco Colonna, Samuel Klein |
Abstract |
An increased number of macrophages in adipose tissue is associated with insulin resistance and metabolic dysfunction in obese people. However, little is known about other immune cells in adipose tissue from obese people, and whether they contribute to insulin resistance. We investigated the characteristics of T cells in adipose tissue from metabolically abnormal insulin-resistant obese (MAO) subjects, metabolically normal insulin-sensitive obese (MNO) subjects, and lean subjects. Insulin sensitivity was determined by using the hyperinsulinemic euglycemic clamp procedure. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Chile | 1 | <1% |
Unknown | 173 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 15% |
Researcher | 24 | 14% |
Student > Bachelor | 16 | 9% |
Student > Master | 15 | 9% |
Student > Postgraduate | 12 | 7% |
Other | 40 | 23% |
Unknown | 42 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 22% |
Agricultural and Biological Sciences | 30 | 17% |
Biochemistry, Genetics and Molecular Biology | 24 | 14% |
Immunology and Microbiology | 17 | 10% |
Engineering | 3 | 2% |
Other | 11 | 6% |
Unknown | 51 | 29% |