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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Meis1 regulates postnatal cardiomyocyte cell cycle arrest
|
|---|---|
| Published in |
Nature, April 2013
|
| DOI | 10.1038/nature12054 |
| Pubmed ID | |
| Authors |
Ahmed I. Mahmoud, Fatih Kocabas, Shalini A. Muralidhar, Wataru Kimura, Ahmed S. Koura, Suwannee Thet, Enzo R. Porrello, Hesham A. Sadek |
| Abstract |
The neonatal mammalian heart is capable of substantial regeneration following injury through cardiomyocyte proliferation. However, this regenerative capacity is lost by postnatal day 7 and the mechanisms of cardiomyocyte cell cycle arrest remain unclear. The homeodomain transcription factor Meis1 is required for normal cardiac development but its role in cardiomyocytes is unknown. Here we identify Meis1 as a critical regulator of the cardiomyocyte cell cycle. Meis1 deletion in mouse cardiomyocytes was sufficient for extension of the postnatal proliferative window of cardiomyocytes, and for re-activation of cardiomyocyte mitosis in the adult heart with no deleterious effect on cardiac function. In contrast, overexpression of Meis1 in cardiomyocytes decreased neonatal myocyte proliferation and inhibited neonatal heart regeneration. Finally, we show that Meis1 is required for transcriptional activation of the synergistic CDK inhibitors p15, p16 and p21. These results identify Meis1 as a critical transcriptional regulator of cardiomyocyte proliferation and a potential therapeutic target for heart regeneration. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 33% |
| United Kingdom | 3 | 14% |
| Spain | 2 | 10% |
| Chile | 1 | 5% |
| Turkey | 1 | 5% |
| France | 1 | 5% |
| Unknown | 6 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 57% |
| Scientists | 7 | 33% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 408 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Japan | 2 | <1% |
| Spain | 2 | <1% |
| Netherlands | 2 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Portugal | 1 | <1% |
| Armenia | 1 | <1% |
| Turkey | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 392 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 111 | 27% |
| Researcher | 78 | 19% |
| Student > Master | 47 | 12% |
| Student > Bachelor | 32 | 8% |
| Student > Doctoral Student | 26 | 6% |
| Other | 48 | 12% |
| Unknown | 66 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 132 | 32% |
| Biochemistry, Genetics and Molecular Biology | 116 | 28% |
| Medicine and Dentistry | 51 | 13% |
| Engineering | 9 | 2% |
| Neuroscience | 6 | 1% |
| Other | 18 | 4% |
| Unknown | 76 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#1,514,368
of 25,837,817 outputs
Outputs from Nature
#38,507
of 98,779 outputs
Outputs of similar age
#11,777
of 212,480 outputs
Outputs of similar age from Nature
#585
of 1,018 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,779 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.5. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,480 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1,018 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.