Title |
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
|
---|---|
Published in |
Nature, October 1999
|
DOI | 10.1038/44385 |
Pubmed ID | |
Authors |
Federica Sallusto, Danielle Lenig, Reinhold Förster, Martin Lipp, Antonio Lanzavecchia |
Abstract |
Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cells. Once activated, they proliferate vigorously, generating effector cells that can migrate to B-cell areas or to inflamed tissues. A fraction of primed T lymphocytes persists as circulating memory cells that can confer protection and give, upon secondary challenge, a qualitatively different and quantitatively enhanced response. The nature of the cells that mediate the different facets of immunological memory remains unresolved. Here we show that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets. CCR7- memory cells express receptors for migration to inflamed tissues and display immediate effector function. In contrast, CCR7+ memory cells express lymph-node homing receptors and lack immediate effector function, but efficiently stimulate dendritic cells and differentiate into CCR7- effector cells upon secondary stimulation. The CCR7+ and CCR7- T cells, which we have named central memory (TCM) and effector memory (TEM), differentiate in a step-wise fashion from naive T cells, persist for years after immunization and allow a division of labour in the memory response. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
Sweden | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
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Scientists | 3 | 50% |
Members of the public | 3 | 50% |
Mendeley readers
Geographical breakdown
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United States | 13 | <1% |
United Kingdom | 6 | <1% |
Netherlands | 5 | <1% |
Canada | 4 | <1% |
Germany | 3 | <1% |
Italy | 2 | <1% |
Portugal | 2 | <1% |
China | 2 | <1% |
South Africa | 2 | <1% |
Other | 15 | <1% |
Unknown | 1547 | 97% |
Demographic breakdown
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Researcher | 281 | 18% |
Student > Master | 204 | 13% |
Student > Bachelor | 132 | 8% |
Student > Doctoral Student | 93 | 6% |
Other | 208 | 13% |
Unknown | 270 | 17% |
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Medicine and Dentistry | 259 | 16% |
Biochemistry, Genetics and Molecular Biology | 168 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | <1% |
Other | 77 | 5% |
Unknown | 288 | 18% |