Title |
Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?
|
---|---|
Published in |
Emerging Infectious Diseases, April 2013
|
DOI | 10.3201/eid0707.010708 |
Pubmed ID | |
Authors |
F. R. Mooi, I. H. van Loo, A. J. King, Mooi, F R, van Loo, I H, King, A J |
Abstract |
In the Netherlands, as in many other western countries, pertussis vaccines have been used extensively for more than 40 years. Therefore, it is conceivable that vaccine-induced immunity has affected the evolution of Bordetella pertussis. Consistent with this notion, pertussis has reemerged in the Netherlands, despite high vaccination coverage. Further, a notable change in the population structure of B. pertussis was observed in the Netherlands subsequent to the introduction of vaccination in the 1950s. Finally, we observed antigenic divergence between clinical isolates and vaccine strains, in particular with respect to the surface-associated proteins pertactin and pertussis toxin. Adaptation may have allowed B. pertussis to remain endemic despite widespread vaccination and may have contributed to the reemergence of pertussis in the Netherlands. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Kuwait | 5 | 17% |
United States | 4 | 13% |
Egypt | 2 | 7% |
Canada | 1 | 3% |
Yemen | 1 | 3% |
Serbia | 1 | 3% |
Belgium | 1 | 3% |
Unknown | 15 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 27 | 90% |
Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Scientists | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 100% |
United States | 1 | 50% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 950% |
Student > Master | 19 | 950% |
Student > Ph. D. Student | 17 | 850% |
Student > Bachelor | 15 | 750% |
Student > Postgraduate | 6 | 300% |
Other | 16 | 800% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 1900% |
Medicine and Dentistry | 15 | 750% |
Immunology and Microbiology | 12 | 600% |
Biochemistry, Genetics and Molecular Biology | 10 | 500% |
Chemical Engineering | 2 | 100% |
Other | 8 | 400% |