| Title |
Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, November 2016
|
| DOI | 10.1007/s13105-016-0532-2 |
| Pubmed ID | |
| Authors |
Sneha Yadav, Virendra Tiwari, Manjari Singh, Rajnish K. Yadav, Subhadeep Roy, Uma Devi, Swetlana Gautam, Jitendra Kumar Rawat, Mohd. Nazam Ansari, Abdulaziz Sa Saeedan, Anand Prakash, Shubhini A. Saraf, Gaurav Kaithwas |
| Abstract |
The present study was undertaken to elucidate the effect of alpha-linolenic acid (ALA, 18:3, ω-3) and gamma-linolenic acid (GLA, 18:3, ω-6) on experimental autism features induced by early prenatal exposure to valproic acid (VPA) in albino wistar pups. The pups were scrutinized on the accounts of behavioral, biochemical, and inflammatory markers, and the results suggested that the GLA can impart significant protection in comparison to ALA against VPA-induced autism features. When scrutinized histopathologically, the cerebellum of the GLA-treated animals was evident for more marked protection toward neuronal degeneration and neuronal loss in comparison to ALA. Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect. Henceforth, it can be concluded that ALA and GLA can impart favorable protection against the VPA-induced autism-like features with GLA having pronounced effect. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 16% |
| Researcher | 9 | 14% |
| Student > Ph. D. Student | 6 | 9% |
| Student > Postgraduate | 4 | 6% |
| Student > Doctoral Student | 3 | 5% |
| Other | 13 | 20% |
| Unknown | 19 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 20% |
| Neuroscience | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Nursing and Health Professions | 3 | 5% |
| Other | 10 | 16% |
| Unknown | 22 | 34% |