| Title |
Estrogen and progesterone receptors: from molecular structures to clinical targets
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2009
|
| DOI | 10.1007/s00018-009-0017-3 |
| Pubmed ID | |
| Authors |
Stephan Ellmann, Heinrich Sticht, Falk Thiel, Matthias W. Beckmann, Reiner Strick, Pamela L. Strissel |
| Abstract |
Research involving estrogen and progesterone receptors (ER and PR) have greatly contributed to our understanding of cell signaling and transcriptional regulation. In addition to the classical ER and PR nuclear actions, new signaling pathways have recently been identified due to ER and PR association with cell membranes and signal transduction proteins. Bio-informatics has unveiled how ER and PR recognize their ligands, selective modulators and co-factors, which has helped to implement them as key targets in the treatment of benign and malignant tumors. Knowledge regarding ER and PR is vast and complex; therefore, this review will focus on their isoforms, signaling pathways, co-activators and co-repressors, which lead to target gene regulation. Moreover it will highlight ER and PR involvement in benign and malignant diseases as well as pharmacological substances influencing cell signaling and provide established and new structural insights into the mechanism of activation and inhibition of these receptors. |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Spain | 2 | 1% |
| Italy | 1 | <1% |
| Switzerland | 1 | <1% |
| Taiwan | 1 | <1% |
| Unknown | 132 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 25% |
| Student > Master | 20 | 14% |
| Researcher | 19 | 14% |
| Student > Bachelor | 13 | 9% |
| Student > Postgraduate | 9 | 6% |
| Other | 21 | 15% |
| Unknown | 22 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 31% |
| Medicine and Dentistry | 27 | 19% |
| Biochemistry, Genetics and Molecular Biology | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Chemistry | 9 | 6% |
| Other | 17 | 12% |
| Unknown | 25 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2022.
All research outputs
#7,591,533
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,602
of 4,151 outputs
Outputs of similar age
#33,301
of 96,087 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#17
of 35 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.