| Title |
An Update on Antidepressant Use in Bipolar Depression
|
|---|---|
| Published in |
Current Psychiatry Reports, October 2012
|
| DOI | 10.1007/s11920-012-0323-6 |
| Pubmed ID | |
| Authors |
Michelle M. Sidor, Glenda M. MacQueen |
| Abstract |
The effective treatment of depression in people with bipolar disorder remains a clinical challenge. The role of antidepressant medication in treating bipolar depression has been controversial. While early studies and meta-analyses supported a role for antidepressant medication, more recent, high quality randomized controlled trials in bipolar depression have generally not demonstrated efficacy for antidepressant medications. Although the risk of affective switch and long-term de-stabilization remains a concern when using antidepressant medications in bipolar disorder, the magnitude of this risk has been difficult to ascertain with confidence. Maintenance use of antidepressant medication has generally not demonstrated a favorable risk-benefit ratio. Future studies should explore the patient characteristics and response patterns that predict a more favorable response profile to antidepressants amongst patients with bipolar disorder so that the medications can be rationally used in those who are most likely to benefit. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 91 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 20% |
| Student > Bachelor | 13 | 14% |
| Student > Doctoral Student | 10 | 11% |
| Student > Ph. D. Student | 8 | 8% |
| Other | 8 | 8% |
| Other | 25 | 26% |
| Unknown | 12 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 38% |
| Psychology | 11 | 12% |
| Agricultural and Biological Sciences | 9 | 9% |
| Neuroscience | 7 | 7% |
| Social Sciences | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 19 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2014.
All research outputs
#17,686,611
of 22,707,247 outputs
Outputs from Current Psychiatry Reports
#993
of 1,186 outputs
Outputs of similar age
#126,494
of 174,275 outputs
Outputs of similar age from Current Psychiatry Reports
#10
of 12 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.