| Title |
Amygdala structure and aggressiveness in borderline personality disorder
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, November 2016
|
| DOI | 10.1007/s00406-016-0747-9 |
| Pubmed ID | |
| Authors |
Falk Mancke, Sabine C. Herpertz, Dusan Hirjak, Rebekka Knies, Katja Bertsch |
| Abstract |
Aggressiveness is considered an important clinical feature of borderline personality disorder (BPD) and has been associated with alterations of the amygdala. However, studies that analyzed the exact location of amygdala alterations associated with aggressiveness in BPD or that systematically compared female and male BPD patients are missing. In the current study, we therefore investigated a sex-mixed sample of BPD patients and healthy volunteers and applied an automated segmentation method that allows the study of both, alterations of amygdala volume and localized amygdala shape. Volumetric results revealed no difference in amygdala volume between BPD patients and healthy volunteers, but a trend for a positive association between volume of the right amygdala and aggressiveness in male BPD patients. Analyses of amygdala shape showed a trend for a group by sex interaction effect in the left laterobasal amygdala, without a difference in subgroup analyses. Finally, regions of the left superficial and laterobasal amygdala of male BPD patients were positively associated with aggressiveness. In sum, our results emphasize the need to consider sex-specific effects and demonstrate a link between male BPD patients' aggressiveness and amygdala regions that are particularly related to social information processing and associative emotional learning. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 12% |
| Student > Master | 6 | 10% |
| Student > Ph. D. Student | 5 | 8% |
| Researcher | 4 | 7% |
| Other | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 28 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 14 | 23% |
| Medicine and Dentistry | 5 | 8% |
| Neuroscience | 4 | 7% |
| Agricultural and Biological Sciences | 2 | 3% |
| Computer Science | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 33 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2016.
All research outputs
#21,162,249
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#1,094
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Outputs of similar age
#353,768
of 419,783 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#12
of 22 outputs
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