You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
|
|---|---|
| Published in |
Retrovirology, April 2013
|
| DOI | 10.1186/1742-4690-10-43 |
| Pubmed ID | |
| Authors |
Michael Roche, Hamid Salimi, Renee Duncan, Brendan L Wilkinson, Kelechi Chikere, Miranda S Moore, Nicholas E Webb, Helena Zappi, Jasminka Sterjovski, Jacqueline K Flynn, Anne Ellett, Lachlan R Gray, Benhur Lee, Becky Jubb, Mike Westby, Paul A Ramsland, Sharon R Lewin, Richard J Payne, Melissa J Churchill, Paul R Gorry |
| Abstract |
The CCR5 antagonist maraviroc (MVC) inhibits human immunodeficiency virus type 1 (HIV-1) entry by altering the CCR5 extracellular loops (ECL), such that the gp120 envelope glycoproteins (Env) no longer recognize CCR5. The mechanisms of HIV-1 resistance to MVC, the only CCR5 antagonist licensed for clinical use are poorly understood, with insights into MVC resistance almost exclusively limited to knowledge obtained from in vitro studies or from studies of resistance to other CCR5 antagonists. To more precisely understand mechanisms of resistance to MVC in vivo, we characterized Envs isolated from 2 subjects who experienced virologic failure on MVC. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 18% |
| Australia | 1 | 9% |
| Canada | 1 | 9% |
| United States | 1 | 9% |
| Germany | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 80 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 16% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 9 | 11% |
| Researcher | 8 | 10% |
| Other | 5 | 6% |
| Other | 13 | 16% |
| Unknown | 21 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 21% |
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Medicine and Dentistry | 8 | 10% |
| Immunology and Microbiology | 7 | 9% |
| Chemistry | 5 | 6% |
| Other | 14 | 17% |
| Unknown | 21 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2016.
All research outputs
#2,137,576
of 23,327,904 outputs
Outputs from Retrovirology
#93
of 1,115 outputs
Outputs of similar age
#18,346
of 198,767 outputs
Outputs of similar age from Retrovirology
#3
of 16 outputs
Altmetric has tracked 23,327,904 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,115 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,767 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.