Title |
Brain tau deposition linked to systemic causes of death in normal elderly
|
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Published in |
Neurobiology of Aging, November 2016
|
DOI | 10.1016/j.neurobiolaging.2016.11.011 |
Pubmed ID | |
Authors |
Keith A. Josephs, Nirubol Tosakulwong, Stephen D. Weigand, Melissa E. Murray, Jennifer L. Whitwell, Joseph E. Parisi, Dennis W. Dickson, Ronald C. Petersen |
Abstract |
The relationship between causes of death and 4 major neurodegenerative brain proteins (beta-amyloid, tau, alpha-synuclein, and the TAR DNA-binding protein of 43 kDa (TDP-43) were assessed in 94 cognitively normal elderly participants that died without a neurodegenerative disease. There was an association between tau and causes of death (p = 0.01). Tau in the brain was associated with a reduced likelihood of dying from systemic cancers (p = 0.046), and with an increased likelihood of dying from pulmonary (p = 0.03) and gastrointestinal (p = 0.049) diseases. There were no associations between beta-amyloid, alpha-synuclein, or TDP-43 and causes of death. Tau deposition in the brain may have a relationship with systemic causes of death, including cancer, in the cognitively normal elderly. |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
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Spain | 1 | 6% |
United States | 1 | 6% |
Unknown | 14 | 88% |
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Researcher | 5 | 31% |
Student > Doctoral Student | 2 | 13% |
Professor | 2 | 13% |
Other | 1 | 6% |
Unspecified | 1 | 6% |
Other | 3 | 19% |
Unknown | 2 | 13% |
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Psychology | 2 | 13% |
Unspecified | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Other | 3 | 19% |
Unknown | 1 | 6% |