| Title |
Genetic characterization of H1N2 swine influenza virus isolated in China and its pathogenesis and inflammatory responses in mice
|
|---|---|
| Published in |
Archives of Virology, April 2013
|
| DOI | 10.1007/s00705-013-1685-8 |
| Pubmed ID | |
| Authors |
Yan Zhang, Nan Wang, Jiyue Cao, Huanchun Chen, Meilin Jin, Hongbo Zhou |
| Abstract |
In 2009, two H1N2 influenza viruses were isolated from trachea swabs of pigs in Hubei in China. We compared these sequences with the other 18 complete genome sequences of swine H1N2 isolates from China during 2004 to 2010 and undertook extensive analysis of their evolutionary patterns. Six different genotypes - two reassortants between triple reassortant (TR) H3N2 and classical swine (CS) H1N1 virus, three reassortants between TR H1N2, Eurasian avian-like H1N1 swine virus and H9N2 swine virus, and one reassortant between H1N1, H3N2 human virus and CS H1N1 virus - were observed in these 20 swine H1N2 isolates. The TR H1N2 swine virus is the predominant genotype, and the two Hubei H1N2 isolates were located in this cluster. We also used a mouse model to examine the pathogenesis and inflammatory responses of the two isolates. The isolates replicated efficiently in the lung, and exhibited a strong inflammatory response, serious pathological changes and mortality in infected mice. Given the role that swine can play as putative "genetic mixing vessels" and the observed transmission of TR H1N2 in ferrets, H1N2 influenza surveillance in pigs should be increased to minimize the potential threat to public health. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Denmark | 1 | 6% |
| Unknown | 15 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 24% |
| Student > Master | 4 | 24% |
| Other | 2 | 12% |
| Student > Bachelor | 2 | 12% |
| Professor | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 2 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 41% |
| Veterinary Science and Veterinary Medicine | 2 | 12% |
| Medicine and Dentistry | 2 | 12% |
| Computer Science | 1 | 6% |
| Earth and Planetary Sciences | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 3 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2013.
All research outputs
#15,270,134
of 22,707,247 outputs
Outputs from Archives of Virology
#2,584
of 4,132 outputs
Outputs of similar age
#123,467
of 197,532 outputs
Outputs of similar age from Archives of Virology
#19
of 22 outputs
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So far Altmetric has tracked 4,132 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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