| Title |
Outcomes of Sentinel Lymph Node-Positive Breast Cancer Patients Treated with Mastectomy Without Axillary Therapy
|
|---|---|
| Published in |
Annals of Surgical Oncology, October 2016
|
| DOI | 10.1245/s10434-016-5605-5 |
| Pubmed ID | |
| Authors |
Elizabeth FitzSullivan, Roland L. Bassett, Henry M. Kuerer, Elizabeth A. Mittendorf, Min Yi, Kelly K. Hunt, Gildy V. Babiera, Abigail S. Caudle, Dalliah M. Black, Isabelle Bedrosian, Chantal Reyna, Mediget Teshome, Funda Meric-Bernstam, Rosa Hwang |
| Abstract |
Early-stage breast cancer patients with minimal axillary disease identified by sentinel lymph node dissection (SLND) have low regional recurrence rates when treated with breast-conserving surgery and radiation therapy (XRT) and many avoid a completion axillary lymph node dissection (CLND). As the incidence of total mastectomy (TM) has increased, it has become important to characterize which TM patients with a positive SLN may not benefit from further axillary treatment. An institutional database was utilized to identify patients treated with a TM for invasive breast cancer and who had a positive SLN from 1994 to 2010. Clinicopathologic factors were analyzed. Regional recurrence rate, recurrence-free survival (RFS), and overall survival (OS) were determined. A total of 525 patients with invasive breast cancer and a positive SLN were treated with TM, including 58 patients who did not have CLND or XRT and 12 patients who did not have CLND but did receive XRT. Median follow-up was 66 months. The incidence of regional recurrence was not significantly different for patients who received no further axillary treatment compared to those who underwent CLND without XRT or those treated with XRT without CLND (10 years rate: 3.8 vs. 1.6 and 0 % respectively). RFS and OS were not significantly different among patients who received no further axillary treatment compared to those who underwent CLND, XRT, or both. In select patients with early-stage breast cancer treated with mastectomy with a positive SLN, CLND may be avoided without adversely affecting recurrence or survival. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 56% |
| Spain | 3 | 12% |
| El Salvador | 1 | 4% |
| Philippines | 1 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 4% |
| Unknown | 5 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 48% |
| Practitioners (doctors, other healthcare professionals) | 8 | 32% |
| Scientists | 5 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 19% |
| Researcher | 7 | 13% |
| Student > Bachelor | 6 | 11% |
| Other | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 9 | 17% |
| Unknown | 14 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 47% |
| Nursing and Health Professions | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Agricultural and Biological Sciences | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 18 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2017.
All research outputs
#2,040,932
of 25,083,571 outputs
Outputs from Annals of Surgical Oncology
#406
of 7,162 outputs
Outputs of similar age
#34,944
of 328,727 outputs
Outputs of similar age from Annals of Surgical Oncology
#9
of 99 outputs
Altmetric has tracked 25,083,571 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,162 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.