| Title |
Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’s Disease: a Review of Current Evidence
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, November 2016
|
| DOI | 10.1007/s12031-016-0857-x |
| Pubmed ID | |
| Authors |
Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Mina Abdolahi, Amir Shayeganrad, Gholamreza Taheri Sangsari, Babak Hassanzadeh Rad, Gerald Muench |
| Abstract |
Alzheimer's disease (AD) is considered as one of the most prevalent neurodegenerative disorders characterized by progressive loss of mental function and ability to learn. AD is a multifactorial disorder. Various hypotheses are suggested for the pathophysiology of AD including "Aβ hypothesis," "tau hypothesis," and "cholinergic hypothesis." Recently, it has been demonstrated that neuroinflammation is involved in the pathogenesis of AD. Neuroinflammation causes synaptic dysfunction and neuronal death within the brain. Excessive production of pro-inflammatory mediators induces Aβ peptide production/accumulation and hyperphosphorylated tau generating inflammatory molecules and cytokines. These inflammatory molecules disrupt blood-brain barrier integrity and increase the production of Aβ42 oligomers. Retinoids and carotenoids are potent antioxidants and anti-inflammatory agents having neuroprotective properties. They are able to prevent disease progression through several mechanisms such as suppression of Aβ peptide production/accumulation, oxidative stress, and pro-inflammatory mediator's secretion as well as improvement of cognitive performance. These observations, therefore, confirm the neuroprotective role of retinoids and carotenoids through multiple pathways. Therefore, the administration of these nutrients is considered as a promising approach to the prevention and/or treatment of AD in the future. The aim of this review is to present existing evidences regarding the beneficial effects of retinoids and carotenoids on AD's risk and outcomes, seeking the mechanism of their action. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 16% |
| Researcher | 15 | 12% |
| Student > Ph. D. Student | 15 | 12% |
| Student > Bachelor | 15 | 12% |
| Student > Doctoral Student | 11 | 9% |
| Other | 18 | 15% |
| Unknown | 28 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 12% |
| Medicine and Dentistry | 13 | 11% |
| Neuroscience | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 10 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 8% |
| Other | 26 | 21% |
| Unknown | 35 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2021.
All research outputs
#3,710,488
of 25,374,917 outputs
Outputs from Journal of Molecular Neuroscience
#157
of 1,643 outputs
Outputs of similar age
#68,367
of 415,799 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#2
of 11 outputs
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So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.