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Norepinephrine Genes Predict Response Time Variability and Methylphenidate-Induced Changes in Neuropsychological Function in Attention Deficit Hyperactivity Disorder

Overview of attention for article published in Journal of Clinical Psychopharmacology, June 2013
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Title
Norepinephrine Genes Predict Response Time Variability and Methylphenidate-Induced Changes in Neuropsychological Function in Attention Deficit Hyperactivity Disorder
Published in
Journal of Clinical Psychopharmacology, June 2013
DOI 10.1097/jcp.0b013e31828f9fc3
Pubmed ID
Authors

Bung-Nyun Kim, Jae-Won Kim, Tarrant D.R. Cummins, Mark A. Bellgrove, Ziarih Hawi, Soon-Beom Hong, Young-Hui Yang, Hyo-Jin Kim, Min-Sup Shin, Soo-Churl Cho, Ji-Hoon Kim, Jung-Woo Son, Yun-Mi Shin, Un-Sun Chung, Doug-Hyun Han

Abstract

Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the α-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.One hundred one medication-naive ADHD children were included. All subjects were administered methylphenidate (MPH)-OROS for 12 weeks. The subjects underwent a computerized comprehensive attention test to measure the response time variability at baseline before MPH treatment and after 12 weeks. Additive regression analyses controlling for ADHD symptom severity, age, sex, IQ, and final dose of MPH examined the association between response time variability on the comprehensive attention test measures and allelic variations in single-nucleotide polymorphisms of the ADRA2A and SLC6A2 before and after MPH treatment.Increasing possession of an A allele at the G1287A polymorphism of SLC6A2 was significantly related to heightened response time variability at baseline in the sustained (P = 2.0 × 10) and auditory selective attention (P = 1.0 × 10) tasks. Response time variability at baseline increased additively with possession of the T allele at the DraI polymorphism of the ADRA2A gene in the auditory selective attention task (P = 2.0 × 10). After medication, increasing possession of a G allele at the MspI polymorphism of the ADRA2A gene was associated with increased MPH-related change in response time variability in the flanker task (P = 1.0 × 10).Our study suggested an association between norepinephrine gene variants and response time variability measured at baseline and after MPH treatment in children with ADHD. Our results add to a growing body of evidence, suggesting that response time variability is a viable endophenotype for ADHD and suggesting its utility as a surrogate end point for measuring stimulant response in pharmacogenetic studies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Brazil 1 1%
Unknown 94 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 11%
Student > Master 11 11%
Student > Bachelor 10 10%
Student > Doctoral Student 9 9%
Student > Ph. D. Student 8 8%
Other 24 25%
Unknown 23 24%
Readers by discipline Count As %
Psychology 25 26%
Medicine and Dentistry 23 24%
Agricultural and Biological Sciences 9 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Neuroscience 3 3%
Other 6 6%
Unknown 23 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2013.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Journal of Clinical Psychopharmacology
#1,768
of 3,101 outputs
Outputs of similar age
#130,276
of 206,481 outputs
Outputs of similar age from Journal of Clinical Psychopharmacology
#10
of 29 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,101 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,481 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.