| Title |
MUTYH-associated colorectal cancer and adenomatous polyposis
|
|---|---|
| Published in |
Surgery Today, April 2013
|
| DOI | 10.1007/s00595-013-0592-7 |
| Pubmed ID | |
| Authors |
Satoru Yamaguchi, Hideo Ogata, Daisuke Katsumata, Masanobu Nakajima, Takaaki Fujii, Soichi Tsutsumi, Takayuki Asao, Kinro Sasaki, Hiroyuki Kuwano, Hiroyuki Kato |
| Abstract |
MUTYH-associated polyposis (MAP) was first described in 2002. MUTYH is a component of a base excision repair system that protects the genomic information from oxidative damage. When the MUTYH gene product is impaired by bi-allelic germline mutation, it leads to the mutation of cancer-related genes, such as the APC and/or the KRAS genes, via G to T transversion. MAP is a hereditary colorectal cancer syndrome inherited in an autosomal-recessive fashion. The clinical features of MAP include the presence of 10-100 adenomatous polyps in the colon, and early onset of colorectal cancer. Ethnic and geographical differences in the pattern of the MUTYH gene mutations have been suggested. In Caucasian patients, c.536A>G (Y179C) and c.1187G>A (G396D) mutations are frequently detected. In the Asian population, Y179C and G396D are uncommon, whereas other variants are suggested to be the major causes of MAP. We herein review the literature on MUTYH-associated colorectal cancer and adenomatous polyposis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Spain | 1 | 2% |
| Unknown | 43 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 18% |
| Researcher | 6 | 13% |
| Student > Bachelor | 5 | 11% |
| Student > Master | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 8 | 18% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 27% |
| Agricultural and Biological Sciences | 11 | 24% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Chemistry | 3 | 7% |
| Social Sciences | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 12 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2014.
All research outputs
#17,687,135
of 22,708,120 outputs
Outputs from Surgery Today
#521
of 988 outputs
Outputs of similar age
#143,023
of 197,527 outputs
Outputs of similar age from Surgery Today
#9
of 20 outputs
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