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The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter

Overview of attention for article published in Human Molecular Genetics, April 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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1 X user
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1 Wikipedia page

Citations

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53 Dimensions

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70 Mendeley
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Title
The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter
Published in
Human Molecular Genetics, April 2013
DOI 10.1093/hmg/ddt175
Pubmed ID
Authors

Jeannette Abplanalp, Endre Laczko, Nancy J. Philp, John Neidhardt, Jurian Zuercher, Philipp Braun, Daniel F. Schorderet, Francis L. Munier, François Verrey, Wolfgang Berger, Simone M.R. Camargo, Barbara Kloeckener-Gruissem

Abstract

Creatine transport has been assigned to creatine transporter 1 (CRT1), encoded by mental retardation associated SLC6A8. Here, we identified a second creatine transporter (CRT2) known as monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12. A non-synonymous alteration in MCT12 (p.G407S) found in a patient with age-related cataract (ARC) leads to a significant reduction of creatine transport. Furthermore, Slc16a12 knockout (KO) rats have elevated creatine levels in urine. Transport activity and expression characteristics of the two creatine transporters are distinct. CRT2 (MCT12)-mediated uptake of creatine was not sensitive to sodium and chloride ions or creatine biosynthesis precursors, breakdown product creatinine or creatine phosphate. Increasing pH correlated with increased creatine uptake. Michaelis-Menten kinetics yielded a Vmax of 838.8 pmol/h/oocyte and a Km of 567.4 µm. Relative expression in various human tissues supports the distinct mutation-associated phenotypes of the two transporters. SLC6A8 was predominantly found in brain, heart and muscle, while SLC16A12 was more abundant in kidney and retina. In the lens, the two transcripts were found at comparable levels. We discuss the distinct, but possibly synergistic functions of the two creatine transporters. Our findings infer potential preventive power of creatine supplementation against the most prominent age-related vision impaired condition.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 20%
Student > Bachelor 10 14%
Researcher 10 14%
Student > Master 6 9%
Student > Doctoral Student 5 7%
Other 9 13%
Unknown 16 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 23%
Agricultural and Biological Sciences 12 17%
Pharmacology, Toxicology and Pharmaceutical Science 10 14%
Medicine and Dentistry 9 13%
Immunology and Microbiology 2 3%
Other 5 7%
Unknown 16 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2018.
All research outputs
#7,356,343
of 25,374,917 outputs
Outputs from Human Molecular Genetics
#3,477
of 8,251 outputs
Outputs of similar age
#59,927
of 212,448 outputs
Outputs of similar age from Human Molecular Genetics
#31
of 93 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 8,251 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,448 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.