| Title |
Mechanisms through which a small protein and lipid preload improves glucose tolerance
|
|---|---|
| Published in |
Diabetologia, July 2015
|
| DOI | 10.1007/s00125-015-3710-9 |
| Pubmed ID | |
| Authors |
Domenico Tricò, Simona Baldi, Alberto Tulipani, Silvia Frascerra, Maria Paula Macedo, Andrea Mari, Ele Ferrannini, Andrea Natali |
| Abstract |
Small protein or lipid preloads are able to improve glucose tolerance to a different extent and through different and poorly defined mechanisms. We aimed at quantifying the effect of a mixed protein and lipid preload and at evaluating the underlying mechanisms. Volunteers with normal (NGT, n = 12) or impaired (IGT, n = 13) glucose tolerance and patients with type 2 diabetes (n = 10) underwent two OGTTs coupled to the double glucose tracer protocol, preceded by either 50 g of parmesan cheese, a boiled egg and 300 ml of water, or 500 ml of water. We measured plasma glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide (PP), NEFA and glucose tracers, and calculated glucose fluxes, beta cell function variables, insulin sensitivity and clearance. After the nutrient preload, the OGTT-induced rise of plasma glucose was lower than after water alone in each study group. This reduction-more pronounced across classes of glucose tolerance (NGT -32%, IGT -37%, type 2 diabetes -49%; p < 0.002)-was the result of different combinations of slower exogenous glucose rate of appearance, improved beta cell function and reduced insulin clearance, in this order of relevance, which were associated with an only mild stimulation of GIP and GLP-1. After a non-glucidic nutrient preload, glucose tolerance improved in proportion to the degree of its baseline deterioration through mechanisms that appear particularly effective in type 2 diabetes. Exploiting the physiological responses to nutrient ingestion might reveal, at least in the first stages of the diabetic disease, a potent tool to improve daily life glycaemic control. ClinicalTrials.gov NCT02342834 FUNDING: : This work was supported by grants from the University of Pisa (Fondi di Ateneo) and by FCT grant (PIC/IC/82956/2007). |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Portugal | 1 | 1% |
| Denmark | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 72 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 13% |
| Student > Bachelor | 9 | 12% |
| Student > Ph. D. Student | 8 | 11% |
| Other | 6 | 8% |
| Researcher | 6 | 8% |
| Other | 12 | 16% |
| Unknown | 25 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 29% |
| Nursing and Health Professions | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Agricultural and Biological Sciences | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 8 | 11% |
| Unknown | 27 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2023.
All research outputs
#511,231
of 24,618,500 outputs
Outputs from Diabetologia
#266
of 5,281 outputs
Outputs of similar age
#5,889
of 268,159 outputs
Outputs of similar age from Diabetologia
#4
of 69 outputs
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